Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert

		BioNMR > NMR community > Online News
Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

06-22-2020, 10:19 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert

Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert

Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search EurekAlert Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search - EurekAlert Clearer understanding of disordered protein could aid ALS, Alzheimer's treatment search EurekAlert Read here	nmrlearner	Online News	0	06-16-2020 01:36 AM
X-ray laser opens new view on Alzheimer's proteins - EurekAlert (press release) X-ray laser opens new view on Alzheimer's proteins - EurekAlert (press release) <img alt="" height="1" width="1"> X-ray laser opens new view on Alzheimer's proteins EurekAlert (press release) "A major part of our understanding about amyloid fibrils is derived from nuclear magnetic resonance (NMR) and cryo-electron microscopy data," explains Seuring. "When you are working with samples that are as heterogeneous as amyloids, though, and also ... Read here	nmrlearner	Online News	0	05-09-2018 03:14 PM
Alzheimer's Tau protein forms toxic complexes with cell membranes - EurekAlert (press release) Alzheimer's Tau protein forms toxic complexes with cell membranes - EurekAlert (press release) <img alt="" height="1" width="1"> Alzheimer's Tau protein forms toxic complexes with cell membranes EurekAlert (press release) In collaboration with Professor David Eliezer at Weill Cornell School of Medical Sciences in New York, the researchers used Nuclear Magnetic Resonance (NMR) to gain insight into the structure of Tau in the core of the complexes. This revealed that the ... and more » Read here	nmrlearner	Online News	0	12-15-2017 07:54 AM
Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... - EurekAlert (press release) http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcSO0MkkUxtPQ4lK58RIiZ3I6PBDLS0IC8TOKFk2eGEQsEQ7UT3TJT4nSpwXD4xz1LnsOr5T6RU5 EurekAlert (press release) <img alt="" height="1" width="1"> Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... EurekAlert (press release) Structural biologists provide a new explanation for how ALS-associated genetic flaws interfere with the proper function and behavior of the protein TDP-43. and more » Study shows how mutations disrupt ALS-linked protein \| EurekAlert ... - EurekAlert (press release)	nmrlearner	Online News	0	08-19-2016 04:05 AM
Alzheimer fibrils at atomic resolution - EurekAlert (press release) <img alt="" height="1" width="1"> Alzheimer fibrils at atomic resolution EurekAlert (press release) Only solid-state nuclear magnetic resonance spectroscopy (solid-state NMR) is capable of offering a view at the atomic level in this case. New developments in methods made it possible to measure a network of distances between the atoms in the protein ... and more » Alzheimer fibrils at atomic resolution - EurekAlert (press release) More...	nmrlearner	Online News	0	08-06-2016 07:22 PM
Structure of Parkinson's protein could lead to new diagnostic and treatment options University of Illinois at Urbana ... - EurekAlert (press release) Structure of Parkinson's protein could lead to new diagnostic and treatment options University of Illinois at Urbana ... - EurekAlert (press release) http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcQ-Dt4oQm5hVIwfhXCfpzOFeRS-Qu-qvV5SexJrJtZk6vKBmwgX4u3eFmr6Hrncnx0C2O5Qub8x EurekAlert (press release) <img alt="" height="1" width="1"> Structure of Parkinson's protein could lead to new diagnostic and treatment options University of Illinois at Urbana ... EurekAlert (press release) CHAMPAIGN, Ill. -- Chemists have identified the complex chemical structure of the protein that...	nmrlearner	Online News	0	03-29-2016 01:43 AM
[NMR paper] Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease. Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease. Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease. Molecules. 2013;18(5):4929-41 Authors: Ramírez-Gualito K, Richter M, Matzapetakis M, Singer D, Berger S Abstract Rational design of peptide vaccines becomes important for the treatment of some diseases such as Alzheimer's disease (AD) and related disorders. In this study, as part of a larger...	nmrlearner	Journal club	0	04-30-2013 10:21 PM
Alzheimer's protein structure suggests new treatment directions - Eureka! Science News http://www.bionmr.com//nt2.ggpht.com/news/tbn/Grqk4iT5yahTiM/6.jpg Eureka! Science News <img alt="" height="1" width="1" /> Alzheimer's protein structure suggests new treatment directions Eureka! Science News The Vanderbilt researchers used nuclear magnetic resonance and electron paragmagnetic resonance spectroscopy to determine the structure of C99, which has one membrane-spanning region. They were surprised to discover what appeared to be a "binding" ... and more » Alzheimer's protein structure suggests new treatment directions - Eureka! Science News	nmrlearner	Online News	0	06-01-2012 07:46 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off