Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net

		BioNMR > NMR community > Online News
Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

09-08-2011, 08:24 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,779

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net

Biochemists reveal interaction between tumor suppressor protein and chaperone - News-Medical.net

Biochemists reveal interaction between tumor suppressor protein and chaperone
News-Medical.net
Using nuclear magnetic resonance (NMR) spectroscopy, the scientists at the Bavarian NMR Center in Garching were able for the first time to characterize the interaction surfaces between Hsp90 and p53 and show that p53 binds to Hsp90 in an already ...

Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design. Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design. Int J Nanomedicine. 2011;6:213-8 Authors: Irani S, Monajjemi M, Honarparvar B, Atyabi S, Sadeghizadeh M Abstract The p53 tumor-suppressor gene encodes a nuclear phosphoprotein with cancer- inhibiting properties. The...	nmrlearner	Journal club	0	08-25-2011 04:10 PM
Proteins Reveal Their Secrets Under Pressure - Chemical & Engineering News Proteins Reveal Their Secrets Under Pressure - Chemical & Engineering News http://nt3.ggpht.com/news/tbn/w_rlCzy1Ripc7M/6.jpg Chemical & Engineering News <img alt="" height="1" width="1" /> Proteins Reveal Their Secrets Under Pressure Chemical & Engineering News With the device, the researchers attempted an NMR experiment they call pressure perturbation transient state spectroscopy. The experiment begins with a pressure spike that unfolds a protein in solution in an NMR sample tube; then the protein refolds ...	nmrlearner	Online News	0	08-02-2011 12:25 AM
Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis - Medical News Today (press release) <img alt="" height="1" width="1" /> Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis Medical News Today (press release) "Our new NG Class Detergents give biologists enhanced tools to solve the structure of membrane proteins using advanced techniques, such as nuclear magnetic resonance and X-ray diffraction." Membrane proteins are important because they mediate the ... and more » Affymetrix Launches NG Classâ?¢ Detergents For Superior Protein Analysis - Medical News Today (press release) More...	nmrlearner	Online News	0	02-17-2011 09:41 AM
[NMR paper] An NMR study of the interaction between the human copper(I) chaperone and the second An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein. Related Articles An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein. FEBS J. 2005 Feb;272(3):865-71 Authors: Banci L, Bertini I, Ciofi-Baffoni S, Chasapis CT, Hadjiliadis N, Rosato A The interaction between the human copper(I) chaperone, HAH1, and one of its two physiological partners, the Menkes disease protein...	nmrlearner	Journal club	0	11-24-2010 11:14 PM
[NMR paper] Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. Related Articles Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data. Protein Sci. 2000 Jun;9(6):1120-8 Authors: Yuan C, Selby TL, Li J, Byeon IJ, Tsai MD Within the tumor suppressor protein INK4 (inhibitor of cyclin-dependent kinase 4) family, p15INK4B is the smallest and the only one whose structure has not been determined...	nmrlearner	Journal club	0	11-18-2010 09:15 PM
Researchers elucidate Qua1 spatial structure region of Sam68 protein - News-Medical.n Researchers elucidate Qua1 spatial structure region of Sam68 protein - News-Medical.net <img alt="" height="1" width="1" /> Researchers elucidate Qua1 spatial structure region of Sam68 protein News-Medical.net Using NMR spectroscopy, Professor Michael Sattler and his team elucidated the spatial structure of the Qua1 region of Sam68, which is responsible for the ... and more » Read here	nmrlearner	Online News	0	09-13-2010 03:33 PM
Structure of key protein for cellular signal transduction elucidated - News-Medical.n Structure of key protein for cellular signal transduction elucidated - News-Medical.net <img alt="" height="1" width="1" /> Structure of key protein for cellular signal transduction elucidated News-Medical.net Using NMR spectroscopy, Professor Michael Sattler and his team elucidated the spatial structure of the Qua1 region of Sam68, which is responsible for the ... and more » Read here	nmrlearner	Online News	0	09-10-2010 12:58 PM
[NMR paper] Tumor suppressor p16INK4A: structural characterization of wild-type and mutant protei Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-acspubs.jpg Related Articles Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism. Biochemistry. 1996 Jul 23;35(29):9475-87 Authors: Tevelev A, Byeon IJ, Selby T, Ericson K, Kim HJ, Kraynov V, Tsai MD The tumor suppressor p16INK4A with eight N-terminal amino acids deleted (p16/delta 1-8)...	nmrlearner	Journal club	0	08-22-2010 02:20 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off