Analytical methods for obtaining HOS information from protein therapeutics - European Pharmaceutical Review

		BioNMR > NMR community > Online News
Analytical methods for obtaining HOS information from protein therapeutics - European Pharmaceutical Review

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

02-29-2020, 09:52 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Analytical methods for obtaining HOS information from protein therapeutics - European Pharmaceutical Review

Analytical methods for obtaining HOS information from protein therapeutics - European Pharmaceutical Review

Analytical methods for obtaining HOS information from protein therapeutics European Pharmaceutical Review Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review How can NMR spectroscopy help protein biopharmaceutical development? - European Pharmaceutical Review How can NMR spectroscopy help protein biopharmaceutical development? European Pharmaceutical Review Read here	nmrlearner	Online News	0	02-29-2020 09:52 PM
Quality assessment of biologics: higher order structure analysis using NMR - European Pharmaceutical Review Quality assessment of biologics: higher order structure analysis using NMR European Pharmaceutical ReviewThe webinar will describe how 2D NMR can offer protein biochemists unprecedented analytical precision. By assigning just one spectrum, users can obtain a ... Quality assessment of biologics: higher order structure analysis using NMR - European Pharmaceutical Review More...	nmrlearner	Online News	0	01-07-2019 05:49 AM
[NMR paper] Chemometric Methods to Quantify 1D and 2D NMR Spectral Differences Among Similar Protein Therapeutics. Chemometric Methods to Quantify 1D and 2D NMR Spectral Differences Among Similar Protein Therapeutics. Related Articles Chemometric Methods to Quantify 1D and 2D NMR Spectral Differences Among Similar Protein Therapeutics. AAPS PharmSciTech. 2017 Nov 06;: Authors: Chen K, Park J, Li F, Patil SM, Keire DA Abstract NMR spectroscopy is an emerging analytical tool for measuring complex drug product qualities, e.g., protein higher order structure (HOS) or heparin chemical composition. Most drug NMR spectra have been visually...	nmrlearner	Journal club	0	11-08-2017 02:52 PM
[NMR paper] 2D (1)H(N), (15)N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies. 2D (1)H(N), (15)N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies. Related Articles 2D (1)H(N), (15)N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies. Pharm Res. 2015 Oct 9; Authors: Arbogast LW, Brinson RG, Formolo T, Hoopes JT, Marino JP Abstract PURPOSE: High-resolution nuclear magnetic resonance spectroscopy (NMR) provides a robust approach for producing unique...	nmrlearner	Journal club	0	10-12-2015 01:04 AM
[NMR paper] Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Related Articles Correction to On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Jun 30; Authors: Poppe L, Jordan JB, Rogers G, Schnier PD PMID: 26125133	nmrlearner	Journal club	0	07-01-2015 02:40 PM
[NMR paper] On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Related Articles On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods. Anal Chem. 2015 Apr 30; Authors: Poppe L, Jordan JB, Rogers G, Schnier PD Abstract An important aspect in the analytical characterization of protein therapeutics is the comprehensive characterization of higher...	nmrlearner	Journal club	0	05-02-2015 09:41 PM
Affymetrix launches NG Class detergents for better protein analysis - Pharmaceutical Business Review <img alt="" height="1" width="1" /> Affymetrix launches NG Class detergents for better protein analysis Pharmaceutical Business Review Affymetrix chief commercial officer Andy Last said the new NG Class Detergents give biologists enhanced tools to solve the structure of membrane proteins using advanced techniques, such as nuclear magnetic resonance and X-ray diffraction. ... and more » Affymetrix launches NG Class detergents for better protein analysis - Pharmaceutical Business Review More...	nmrlearner	Online News	0	02-15-2011 09:29 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off