Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress

		BioNMR > NMR community > Online News
Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

11-22-2017, 02:01 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress

Alzheimer's Tau protein forms toxic complexes with cell membranes - Medical Xpress

Medical Xpress

Alzheimer's Tau protein forms toxic complexes with cell membranes
Medical Xpress
The brains of patients with Alzheimer's disease contain characteristic tangles inside neurons. These tangles are formed when a protein called Tau aggregates into twisted fibrils. As a result, the neurons' transport systems ...

and more »
Read here

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Tackling infectious disease â?? one protein at a time - Medical Xpress Tackling infectious disease â?? one protein at a time - Medical Xpress http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSQf2rmna6Lj7mu6Vi03e-sET181eWFZI-PxGPbYTvbPUWLIjvCCPQsAHQBN_0-CiVjPNXVaE9O Medical Xpress <img alt="" height="1" width="1"> Tackling infectious disease â?? one protein at a time Medical Xpress Garry Buchko and colleagues used NMR to solve the structure of the protein, which is found in an infection often conveyed by ticks. Credit: SSGCID. This week the team reached a milestone, announcing that its scientists have solved the 3-D structure of ...	nmrlearner	Online News	0	06-10-2017 05:21 PM
Researchers focus on cell membranes to develop Alzheimer's ... - Science Daily http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSk9DVaZBLNsHjBmTDgD4gJ20XgNllBuUlwlEtJR8kEpr08gPCB6x7xum3zJSyo2GIakkMUgjxV ReliaWire <img alt="" height="1" width="1"> Researchers focus on cell membranes to develop Alzheimer's ... Science Daily Thin parts of the cell membranes of neurons turn out to be particularly vulnerable to a protein that collects in the brain of people with Alzheimer's disease, ... Thinner Neuronal Membranes Provide Amyloid-beta Access PointsReliaWire all 2 news articles »	nmrlearner	Online News	0	03-26-2017 11:10 PM
The amyloid protein alpha-synuclein has been visualised in the cell for the first time - Medical Xpress The amyloid protein alpha-synuclein has been visualised in the cell for the first time - Medical Xpress http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcS9UjyJ8DXb-FoY-20X-NIjcDfjERVtYq9chNj-0CgY9D3nRl8SdgkiedqjlR7pLdKeKTwmXsAXDQ Medical Xpress <img alt="" height="1" width="1"> The amyloid protein alpha-synuclein has been visualised in the cell for the first time Medical Xpress This was made possible by a combination of nuclear magnetic resonance spectroscopy (NMR) and electron paramagnetic resonance spectroscopy (EPR), two procedures that make it possible to characterise the...	nmrlearner	Online News	0	01-26-2016 03:40 PM
Structure of Alzheimer's protein could explain why it's toxic - RedOrbit Structure of Alzheimer's protein could explain why it's toxic - RedOrbit http://www.bionmr.com//t2.gstatic.com/images?q=tbn:ANd9GcTaOejFkg42-j_AVBYusnE8YNsSalitK4LWGRXBkENCbN-2tHybo_apRX6dQCQ3C-iGEcRc65o RedOrbit <img alt="" height="1" width="1"> Structure of Alzheimer's protein could explain why it's toxic RedOrbit Furthermore, as they report in the journal Nature Structural and Molecular Biology, there is an amino acid on the protein that forms a bond between positive and negative-charged parts of a molecule known as a salt bridge. This structure is ... and more »	nmrlearner	Online News	0	05-14-2015 04:52 AM
How pairs of proteins collaborate to splice RNAs into cell-specific products - Medical Xpress How pairs of proteins collaborate to splice RNAs into cell-specific products - Medical Xpress http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSi8ogLDL6QedQVbWENKWKi4wq3MYFedAHzNaB0nBgDNzDcyhhaO_KI1kqDEaYbBWgV21SnYgmg Medical Xpress <img alt="" height="1" width="1" /> How pairs of proteins collaborate to splice RNAs into cell-specific products Medical Xpress Detailed structural analysis using nuclear magnetic resonance (NMR) techniques revealed that ASD-1 RRM binding initiates a rearrangement in the RNA that favors SUP-12 RRM binding, resulting in a distinctive complex in...	nmrlearner	Online News	0	10-17-2014 04:48 PM
Protein's structural shift offers clues to tumor suppression and other key ... - Medical Xpress Protein's structural shift offers clues to tumor suppression and other key ... - Medical Xpress <img alt="" height="1" width="1" /> Protein's structural shift offers clues to tumor suppression and other key ... Medical Xpress Using nuclear magnetic resonance (NMR) and other techniques, researchers identified a regulatory mechanism that prompted the NPM1 segment to partially or completely unfold into a single disordered strand of amino acids. The researchers believe that the ... Read here	nmrlearner	Online News	0	07-04-2014 08:28 PM
The antioxidant role of proteins containing selenium - Medical Xpress http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcSFmjKJueH8sAToPwf6NTRqSMgpmXF5eN5IlNWIrF-aWjIE0gtwFZ4ekXGsw23ht2fak3YoJkNr Medical Xpress <img alt="" height="1" width="1" /> The antioxidant role of proteins containing selenium Medical Xpress Rozovsky and her team used mass spectrometry and nuclear magnetic resonance spectroscopy to study selenium in redox biology, which the journal called a new approach that deepens scientific understanding of the chemical properties involved. Rozovsky ... The antioxidant role of proteins containing selenium - Medical Xpress	nmrlearner	Online News	0	04-28-2014 10:34 PM
Researchers identify new protein markers that may improve understanding of ... - Medical Xpress Researchers identify new protein markers that may improve understanding of ... - Medical Xpress <img alt="" height="1" width="1" /> Researchers identify new protein markers that may improve understanding of ... Medical Xpress Testing for GlycA and GlycB by NMR spectroscopy uses signals that arise from the binding of glucose molecules to a variety of circulating inflammatory proteins, especially fibrinogen, Î±1-antichymotrypsin, haptoglobin-1, Î±1-antitrypsin, complement C3 ... and more » Read here	nmrlearner	Online News	0	03-30-2014 06:49 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off