[NMR paper] AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures
AlphaFold Models of Small Proteins Rival the Accuracy of Solution NMR Structures
Recent advances in molecular modeling using deep learning have the potential to revolutionize the field of structural biology. In particular, AlphaFold has been observed to provide models of protein structures with accuracies rivaling medium-resolution X-ray crystal structures, and with excellent atomic coordinate matches to experimental protein NMR and cryo-electron microscopy structures. Here we assess the hypothesis that AlphaFold models of small, relatively rigid proteins have accuracies...
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06-30-2022 11:57 AM
[NMR paper] The accuracy of protein structures in solution determined by AlphaFold and NMR
The accuracy of protein structures in solution determined by AlphaFold and NMR
AlphaFoldn the recent Critical Assessment of Structure Prediction (CASP) competition, AlphaFold2 performed outstandingly. Its worst predictions were for nuclear magnetic resonance (NMR) structures, which has two alternative explanations: either the NMR structures were poor, implying that Alpha-Fold may be more accurate than NMR, or there is a genuine difference between crystal and solution structures. Here, we use the program Accuracy of NMR Structures Using RCI and Rigidity (ANSURR), which...
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[NMR paper] Chemical shifts-based similarity restraints improve accuracy of RNA structures determined via NMR.
Chemical shifts-based similarity restraints improve accuracy of RNA structures determined via NMR.
Chemical shifts-based similarity restraints improve accuracy of RNA structures determined via NMR.
RNA. 2020 Sep 11;:
Authors: Lawrence C, Grishaev AV
Abstract
Determination of structure of RNA via NMR is complicated in large part by the lack of a precise parameterization linking the observed chemical shifts to the underlying geometric parameters. In contrast to proteins, where numerous high-resolution crystal structures serve as...
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09-15-2020 04:44 AM
Accuracy and precision of protein structures determined by magic angle spinning NMR spectroscopy: for some â??with a little help from a friendâ??
Accuracy and precision of protein structures determined by magic angle spinning NMR spectroscopy: for some â??with a little help from a friendâ??
Abstract
We present a systematic investigation into the attainable accuracy and precision of protein structures determined by heteronuclear magic angle spinning solid-state NMR for a set of four proteins of varied size and secondary structure content. Structures were calculated using synthetically generated random sets of C-C distances up to 7Â*Ã? at different degrees of completeness. For single-domain...
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03-24-2019 10:41 PM
[NMR paper] An assessment of the precision and accuracy of protein structures determined by NMR.
An assessment of the precision and accuracy of protein structures determined by NMR. Dependence on distance errors.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles An assessment of the precision and accuracy of protein structures determined by NMR. Dependence on distance errors.
J Mol Biol. 1994 Jun 24;239(5):601-7
Authors: Zhao D, Jardetzky O
We tested the dependence of the accuracy and precision of calculated NMR structures on the errors of the distance constraints...
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08-22-2010 03:33 AM
[NMR paper] An assessment of the precision and accuracy of protein structures determined by NMR.
An assessment of the precision and accuracy of protein structures determined by NMR. Dependence on distance errors.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles An assessment of the precision and accuracy of protein structures determined by NMR. Dependence on distance errors.
J Mol Biol. 1994 Jun 24;239(5):601-7
Authors: Zhao D, Jardetzky O
We tested the dependence of the accuracy and precision of calculated NMR structures on the errors of the distance constraints...
The accuracy of protein structures in solution determined by AlphaFold and NMR - ScienceDirect.com
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