3D Proteins: Getting the Big Picture - Drug Discovery & Development
3D Proteins: Getting the Big Picture - Drug Discovery & Development
Drug Discovery & Development 3D Proteins: Getting the Big Picture Drug Discovery & Development
For decades, with funding from the National Science Foundation (NSF), Hinton has used nuclear magnetic resonance (NMR) to look at protein structure and function. But he wanted to find a way to educate and engage students about his discoveries. ...
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
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Researchers Look at Averting Drug Resistance
Drug Discovery & Development
Kern and her team studied the protein using nuclear magnetic resonance spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transportingâ??moving the drug from the inside of the cell ...
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
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[NMR paper] NMR in the acceleration of drug discovery.
NMR in the acceleration of drug discovery.
Related Articles NMR in the acceleration of drug discovery.
Curr Opin Drug Discov Devel. 2001 Jul;4(4):479-92
Authors: Sem DS, Pellecchia M
The field of NMR spectroscopy has grown beyond expectations from the first historic observation of nuclear magnetic resonance in 1946 by Bloch and Purcell, to the first generation of protein structures 20 years ago, to the present where NMR structures now represent 15 to 20% of those submitted to the Protein Data Bank (PDB). However, the applications of NMR go far...
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11-19-2010 08:44 PM
[NMR paper] Applications of NMR in drug discovery.
Applications of NMR in drug discovery.
Related Articles Applications of NMR in drug discovery.
Drug Discov Today. 2000 Jun;5(6):230-240
Authors: Roberts GC
In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10-15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein-ligand interactions. These form the basis for its most...
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11-18-2010 09:15 PM
Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News To
Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News Today (press release)
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Purifying Proteins: Researchers Use NMR To Improve Drug Development
Medical News Today (press release)
From the NMR data, they were able to determine what part and type of the protein the ligands were binding to and how strongly they would bind. ...
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Purifying proteins: Rensselaer researchers use NMR to improve drug development - Eure
Purifying proteins: Rensselaer researchers use NMR to improve drug development - EurekAlert (press release)
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Purifying proteins: Rensselaer researchers use NMR to improve drug development
EurekAlert (press release)
IMAGE: NMR reveals the binding sites on a protein. The more selective the ligand is at binding to a specific protein, the more efficient the process is, ...
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09-29-2010 10:40 PM
[NMR paper] NMR screening in drug discovery.
NMR screening in drug discovery.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR screening in drug discovery.
Curr Opin Biotechnol. 1999 Feb;10(1):54-8
Authors: Moore JM
NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...
3D Proteins: Getting the Big Picture - Drug Discovery & Development
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