[NMR paper] AlphaFold 2 and NMR Spectroscopy: Partners to Understand Protein Structure, Dynamics and Function
AlphaFold 2 and NMR Spectroscopy: Partners to Understand Protein Structure, Dynamics and Function
The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure determination as it accurately predicts the 3D structure of two thirds of the human proteome. Its predictions can be used directly as structural models or indirectly as aids for experimental structure determination using X-ray crystallography, CryoEM or NMR spectroscopy. Nevertheless, AlphaFold 2 can neither afford insight into how proteins fold, nor can it determine protein stability or...
nmrlearner
Journal club
0
06-03-2022 07:40 PM
[NMR paper] The accuracy of protein structures in solution determined by AlphaFold and NMR
The accuracy of protein structures in solution determined by AlphaFold and NMR
AlphaFoldn the recent Critical Assessment of Structure Prediction (CASP) competition, AlphaFold2 performed outstandingly. Its worst predictions were for nuclear magnetic resonance (NMR) structures, which has two alternative explanations: either the NMR structures were poor, implying that Alpha-Fold may be more accurate than NMR, or there is a genuine difference between crystal and solution structures. Here, we use the program Accuracy of NMR Structures Using RCI and Rigidity (ANSURR), which...
More...
Systems-level Thinking Helps to Address Protein Folding - Institute for Ethics and Emerging Technologies
Systems-level Thinking Helps to Address Protein Folding - Institute for Ethics and Emerging Technologies
<img alt="" height="1" width="1" />
Systems-level Thinking Helps to Address Protein Folding
Institute for Ethics and Emerging Technologies
There has been much technological advance in determining the static and dynamic features of protein structures, including in X-ray crystallography, NMR (nuclear magnetic resonance spectroscopy), cryo-electron microscopy, small-angle X-ray scattering ...
Read here