[NMR paper] MD Simulations to Calculate NMR Relaxation Parameters of Vanadium(IV) Complexes: A Promising Diagnostic Tool for Cancer and Alzheimer's Disease
MD Simulations to Calculate NMR Relaxation Parameters of Vanadium(IV) Complexes: A Promising Diagnostic Tool for Cancer and Alzheimer's Disease
Early phase diagnosis of human diseases has still been a challenge in the medicinal field, and one of the efficient non-invasive techniques that is vastly used for this purpose is magnetic resonance imaging (MRI). MRI is able to detect a wide range of diseases and conditions, including nervous system disorders and cancer, and uses the principles of NMR relaxation to generate detailed internal images of the body. For such investigation, different...
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12-23-2023 11:47 PM
[NMR paper] 19F NMR: A promising tool for dynamic conformational studies of G protein-coupled receptors
19F NMR: A promising tool for dynamic conformational studies of G protein-coupled receptors
Advances in X-ray crystallography and cryoelectron microscopy enabled unprecedented insights into the activation processes of G protein-coupled receptors (GPCRs). However, these static receptor structures provide limited information about dynamics and conformational transitions that play pivotal roles in mediating signaling diversity through the multifaceted interactions between ligands, receptors, and transducers. Developing NMR approaches to probe the dynamics of conformational transitions...
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09-23-2022 06:24 AM
[NMR paper] Magic angle spinning NMR of G protein-coupled receptors
Magic angle spinning NMR of G protein-coupled receptors
G protein-coupled receptors (GPCRs) have a simple seven transmembrane helix architecture which has evolved to recognize a diverse number of chemical signals. The more than 800 GPCRs encoded in the human genome function as receptors for vision, smell and taste, and mediate key physiological processes. Consequently, these receptors are a major target for pharmaceuticals. Protein crystallography and electron cryo-microscopy have provided high resolution structures of many GPCRs in both active and...
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03-18-2022 12:01 AM
[NMR paper] Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for 19 F-NMR studies in solution.
Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for 19 F-NMR studies in solution.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7388-69-wiley-full-text.png Related Articles Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for 19 F-NMR studies in solution.
FEBS J. 2020 Dec 23;:
Authors: Wang H, Hu W, Liu D, Wüthrich K
Abstract
The human glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are...
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12-30-2020 11:21 AM
[NMR paper] Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors.
Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors.
Related Articles Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors.
FEBS Lett. 2019 Apr 05;:
Authors: Hu W, Wang H, Hou Y, Hao Y, Liu D
Abstract
Large membrane proteins such as G Protein-Coupled Receptors (GPCRs) are difficult for NMR study due to severe signal overlaps and unfavorable relaxation properties. We used a trimethylsilyl (TMS) group as a reporter group for 1 H...
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04-07-2019 05:52 PM
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
Global G-Protein Coupled Receptors (GPCRs) Industry - Sacramento Bee
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Global G-Protein Coupled Receptors (GPCRs) Industry
Sacramento Bee
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in ... NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures II-4 ...
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06-13-2012 11:34 AM
Structure and function of G protein-coupled receptors using NMR spectroscopy
Structure and function of G protein-coupled receptors using NMR spectroscopy
Publication year: 2010
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 57, Issue 2</br>
Joseph A. Goncalves, Shivani Ahuja, Sina Erfani, Markus Eilers, Steven O. Smith</br>
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03-09-2012 09:16 AM
Structure and function of G protein-coupled receptors using NMR spectroscopy
Structure and function of G protein-coupled receptors using NMR spectroscopy
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 12 May 2010</br>
Joseph A., Goncalves , Shivani, Ahuja , Sina, Erfani , Markus, Eilers , Steven O., Smith</br>
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