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1/11/2010 8:50:16 AM GMT
Understanding NMR Spectroscopy More...
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Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping.
Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping.
Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping.
Bioorg Med Chem. 2011 May 1;19(9):3022-8
Authors: Zoia L, Perazzini R, Crestini C, Argyropoulos DS
Abstract
In this paper, we use our quantitative (31)P NMR spin trapping methods, already developed for simple oxygen- and carbon-centered radicals, to understand the radical intermediates generated by enzymatic systems and more specifically lipoxygenases. Our methodology...
nmrlearner
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08-25-2011 04:10 PM
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Chem Biol Drug Des. 2011 May;77(5):301-8
Authors: Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle IR, Endicott JA, McDonnell JM
The interaction between murine double minute (MDM2) and p53 is a major target in anticancer drug design. Several potent compound series, including the nutlins...
nmrlearner
Journal club
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08-05-2011 11:48 AM
Researchers closer to understanding cell-division gatekeeper enzyme - PhysOrg.com
<img alt="" height="1" width="1" />
Researchers closer to understanding cell-division gatekeeper enzyme
PhysOrg.com
The researchers previously used nuclear magnetic resonance (NMR) to measure the ligand dynamics of cis and trans bound to the protein (reported in the Journal of the American Chemical Society, April 1, 2010). Etzkorn explains that cis binds solely to ...
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Researchers closer to understanding cell-division gatekeeper enzyme - PhysOrg.com
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nmrlearner
Online News
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07-06-2011 06:21 PM
[Question from NMRWiki Q&A forum] Beginner: Help understanding 3D NOESY
Beginner: Help understanding 3D NOESY
Hi, I am a person with a Computer Science background who is dealing with some NMR dataset. I am concerned with the assignment of NMR peaks from several experiments. For structure determination, I am dealing with 3D-NOESY data. I am finding it a little hard to comprehend what the several peaks mean here. I understand what the peaks in a 2D dataset like 1H-1H NOESY dataset mean but not on higher dimensions.
I do not understand the nomenclature followed in the naming of NOESY experiments because I feel a little lost in all the technical details in the...
nmrlearner
News from other NMR forums
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06-10-2011 01:41 AM
Towards a structural understanding of the smallest known oncoprotein: Investigation o
Towards a structural understanding of the smallest known oncoprotein: Investigation of the Bovine Papillomavirus E5 protein using solution-state NMR.
Related Articles Towards a structural understanding of the smallest known oncoprotein: Investigation of the Bovine Papillomavirus E5 protein using solution-state NMR.
Biochim Biophys Acta. 2010 Nov 9;
Authors: King G, Oates J, Patel D, van den Berg HA, Dixon AM
The homo-dimeric E5 protein from Bovine Papillomavirus activates the platelet-derived growth factor ? receptor through transmembrane (TM)...
Understanding NMR Spectroscopy
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