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Structural Biochemistry/Proteins/NMR Spectroscopy More...
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[NMR paper] The Use of Amphipols for NMR Structural Characterization of 7-TM Proteins.
The Use of Amphipols for NMR Structural Characterization of 7-TM Proteins.
The Use of Amphipols for NMR Structural Characterization of 7-TM Proteins.
J Membr Biol. 2014 May 25;
Authors: Elter S, Raschle T, Arens S, Viegas A, Gelev V, Etzkorn M, Wagner G
Abstract
While amphipols have been proven useful for refolding of seven transmembrane helical (7-TM) proteins including G-protein-coupled receptors (GPCRs) and it could be shown that an amphipol environment is in principle suitable for NMR structural studies of the embedded...
[NMR paper] NMR Structural Studies of Human Cellular Prion Proteins.
NMR Structural Studies of Human Cellular Prion Proteins.
Related Articles NMR Structural Studies of Human Cellular Prion Proteins.
Curr Top Med Chem. 2013 Sep 23;
Authors: Biljan I, Ilc G, Giachin G, Legname G, Plavec J
Abstract
Prion diseases or transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders associated with the conformational conversion of the cellular prion protein, PrPC, into a pathological form known as prion or PrPSc. They can be classified into sporadic, inherited and infectious forms....
[NMR paper] Structural characterization of intrinsically disordered proteins by NMR spectroscopy.
Structural characterization of intrinsically disordered proteins by NMR spectroscopy.
Structural characterization of intrinsically disordered proteins by NMR spectroscopy.
Molecules. 2013;18(9):10802-28
Authors: Kosol S, Contreras-Martos S, Cedeño C, Tompa P
Abstract
Recent advances in NMR methodology and techniques allow the structural investigation of biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well-suited for the study of intrinsically disordered proteins (IDPs) and intrinsically disordered...
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09-07-2013 09:54 PM
NMR-based structural biology of proteins in supercooled water.
NMR-based structural biology of proteins in supercooled water.
NMR-based structural biology of proteins in supercooled water.
J Struct Funct Genomics. 2011 May 1;
Authors: Szyperski T, Mills JL
NMR-based structural biology of proteins can be pursued efficiently in supercooled water at temperatures well below the freezing point of water. This enables one to study protein structure, dynamics, hydration and cold denaturation in an unperturbed aqueous solution at very low temperatures. Furthermore, such studies enable one to accurately measure...
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05-03-2011 03:20 PM
[NMR paper] NMR structural studies on antifreeze proteins.
NMR structural studies on antifreeze proteins.
Related Articles NMR structural studies on antifreeze proteins.
Biochem Cell Biol. 1998;76(2-3):284-93
Authors: Sönnichsen FD, Davies PL, Sykes BD
Antifreeze proteins (AFPs) are a structurally diverse class of proteins that bind to ice and inhibit its growth in a noncolligative manner. This adsorption-inhibition mechanism operating at the ice surface results in a lowering of the (nonequilibrium) freezing point below the melting point. A lowering of approximately 1 degree C, which is sufficient to...
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11-17-2010 11:06 PM
Postdoctoral positions in Biochemistry and Structural Biology
Postdoctoral positions in Biochemistry and Structural Biology
Two postdoc positions are currently available in the laboratory of Dr. Jamil Saad at the University of Alabama at Birmingham (UAB).
Our research program is aimed at understanding the precise molecular mechanism of how retroviral proteins interact with cellular factors during the virus replication cycle. We use a set of biochemical, biophysical and structural biology (mainly NMR and occasionally X-ray) tools to characterize key protein-protein and protein-lipid interactions critical for vi…
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