Special Applications: NMR Drug Screening, Automation, and so on
22/04/2014 3:22:09 AM GMT
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[NMR paper] Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Related Articles Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits.
Biochem Biophys Res Commun. 2014 Feb 10;
Authors: Lindert S, Maslennikov I, Chiu E, Pierce LC, Andrew McCammon J, Choe S
Abstract
About 8,000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate...
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02-15-2014 08:52 PM
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits
Drug screening strategy for human membrane proteins: from NMR protein backbone structure to in silica- and NMR-screened hits
Publication date: Available online 10 February 2014
Source:Biochemical and Biophysical Research Communications</br>
Author(s): Steffen Lindert , Innokentiy Maslennikov , Ellis Chiu , Levi C Pierce , J. Andrew McCammon , Senyon Choe</br>
About 8,000 genes encode membrane proteins in the human genome. The information about their druggability will be very useful to facilitate drug discovery and development. The main problem, however,...
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02-10-2014 08:46 PM
[NMR paper] Recent applications of isotopic labeling for protein NMR in drug discovery.
Recent applications of isotopic labeling for protein NMR in drug discovery.
Related Articles Recent applications of isotopic labeling for protein NMR in drug discovery.
Expert Opin Drug Discov. 2013 Mar 12;
Authors: Hiroaki H
Abstract
Introduction: Nuclear magnetic resonance (NMR) applications in drug discovery are classified into two categories: ligand-based methods and protein-based methods. The latter is based on the observation of the (1)H-(15)N HSQC spectra of a protein with and without lead compounds. However, in order to take this...
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03-14-2013 10:05 PM
[NMR paper] Sensitivity improvement in 19F NMR-based screening experiments: theoretical considerations and experimental applications.
Sensitivity improvement in 19F NMR-based screening experiments: theoretical considerations and experimental applications.
Related Articles Sensitivity improvement in 19F NMR-based screening experiments: theoretical considerations and experimental applications.
J Am Chem Soc. 2005 Sep 28;127(38):13380-5
Authors: Dalvit C, Mongelli N, Papeo G, Giordano P, Veronesi M, Moskau D, Kümmerle R
NMR-based binding and functional screening performed with FAXS (fluorine chemical shift anisotropy and exchange for screening) and 3-FABS (three fluorine atoms...
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12-01-2010 06:56 PM
[NMR paper] Leveraging structural approaches: applications of NMR-based screening and X-ray cryst
Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.
Related Articles Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design.
J Synchrotron Radiat. 2004 Jan 1;11(Pt 1):97-100
Authors: Moore J, Abdul-Manan N, Fejzo J, Jacobs M, Lepre C, Peng J, Xie X
In the last several years, NMR strategies in drug discovery have evolved from a primarily structural focus to a set of technologies that are non-structural in nature but...
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11-24-2010 09:16 PM
[NMR paper] Applications of NMR in drug discovery.
Applications of NMR in drug discovery.
Related Articles Applications of NMR in drug discovery.
Drug Discov Today. 2000 Jun;5(6):230-240
Authors: Roberts GC
In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10-15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein-ligand interactions. These form the basis for its most...
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11-18-2010 09:15 PM
NMR Screening and Hit Validation in Fragment Based Drug Discovery.
NMR Screening and Hit Validation in Fragment Based Drug Discovery.
Related Articles NMR Screening and Hit Validation in Fragment Based Drug Discovery.
Curr Top Med Chem. 2010 Sep 2;
Authors: Campos-Olivas R
Over the past three decades nuclear magnetic resonance spectroscopy has been developed into a mature technique for the characterization of interactions of small molecule ligands with their corresponding protein and nucleic acid receptors. In fact, a significant number of industrial and academic laboratories employ NMR for screening small...
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09-03-2010 02:30 PM
[NMR paper] NMR screening in drug discovery.
NMR screening in drug discovery.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR screening in drug discovery.
Curr Opin Biotechnol. 1999 Feb;10(1):54-8
Authors: Moore JM
NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...
Special Applications: NMR Drug Screening, Automation, and so on
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