Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Understanding small-molecule binding to MDM2: insights into structural effects of isoindolinone inhibitors from NMR spectroscopy.
Chem Biol Drug Des. 2011 May;77(5):301-8
Authors: Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle IR, Endicott JA, McDonnell JM
The interaction between murine double minute (MDM2) and p53 is a major target in anticancer drug design. Several potent compound series, including the nutlins...
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[Question from NMRWiki Q&A forum] Beginner: Help understanding 3D NOESY
Beginner: Help understanding 3D NOESY
Hi, I am a person with a Computer Science background who is dealing with some NMR dataset. I am concerned with the assignment of NMR peaks from several experiments. For structure determination, I am dealing with 3D-NOESY data. I am finding it a little hard to comprehend what the several peaks mean here. I understand what the peaks in a 2D dataset like 1H-1H NOESY dataset mean but not on higher dimensions.
I do not understand the nomenclature followed in the naming of NOESY experiments because I feel a little lost in all the technical details in the...
Towards a structural understanding of the smallest known oncoprotein: Investigation o
Towards a structural understanding of the smallest known oncoprotein: Investigation of the Bovine Papillomavirus E5 protein using solution-state NMR.
Related Articles Towards a structural understanding of the smallest known oncoprotein: Investigation of the Bovine Papillomavirus E5 protein using solution-state NMR.
Biochim Biophys Acta. 2010 Nov 9;
Authors: King G, Oates J, Patel D, van den Berg HA, Dixon AM
The homo-dimeric E5 protein from Bovine Papillomavirus activates the platelet-derived growth factor ? receptor through transmembrane (TM)...