A recent paper in Science highlights once again the potential of NMR to yield insights into complex molecular recognition events in critical biological processes.
In this case the authors used a combination of X-ray crystallography and NMR to probe the structure of the extracellular terminus of the CCR5 co-receptor which, in concert with human CD4 and HIV gp120, is crucial for viral entry. The authors applied challenging saturation transfer effects to study the structure of a small synthetic peptide in a ternary complex with two large proteins. The structure of the CCR5 epitope was successfully elucidated and provides essential insights into conserved interactions for viral recognition – even at the level of a single nitrogen atom! This important work opens a new and therefore invaluable avenue into the design of new molecules as drugs for AIDS.
Postoctoral position in Structural Biology
Postoctoral position in Structural Biology
UNIVERSITY OF OXFORD
DEPARTMENT OF BIOCHEMISTRY
Postdoctoral Research Associate in Structural Biology
We are seeking to appoint a highly motivated Postdoctoral Research
Associate in the laboratory of Dr. Ioannis Vakonakis for studies of
proteins involved in centriole assembly. The successful candidate will
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a new d...
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nmrlearner
Job marketplace
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01-26-2011 04:21 AM
Small molecules may prevent ebola infection - PhysOrg.com
<img alt="" height="1" width="1" />
Small molecules may prevent ebola infection
PhysOrg.com
Exactly how and where these small molecules bind to the virus's protein coat is now being determined through nuclear magnetic resonance spectroscopy, ...
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Small molecules may prevent ebola infection - PhysOrg.com
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nmrlearner
Online News
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01-20-2011 03:28 AM
[NMR paper] An account of NMR in structural biology.
An account of NMR in structural biology.
Related Articles An account of NMR in structural biology.
Nat Struct Biol. 1997 Oct;4 Suppl:841-4
Authors: Wagner G
With the ability to determine atomic resolution structures of biological macromolecules in semi-physiological conditions, nuclear magnetic resonance spectroscopy (NMR) has become an eminent tool in structural biology. NMR provides a means for studying critical biological phenomena including protein structure, dynamics and folding as well as a practical approach to drug design.
nmrlearner
Journal club
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08-22-2010 05:08 PM
[Nature network NMR forum] NMR, Biophysics, or Structural Biology Blogs (3 replies)
NMR, Biophysics, or Structural Biology Blogs (3 replies)
Hello All,
I get the feeling that most physical/biological science types don’t keep blogs as much as other disciplines, although I would be happy if I am completely mistaken in this. That being said, does anyone have any suggestions of individuals’ or groups’ blogs about NMR specifically, but more broadly about biophysics, or structural biology, or anything along those lines? The only things I have found to follow are Sandwalk , Everyday Scientist , Chemical Musings , and the Disgruntled and Skeptical chemists. All...
nmrlearner
News from other NMR forums
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08-21-2010 03:29 PM
[Nature network NMR forum] Journal club: recombinant RNA expression (0 replies)
Journal club: recombinant RNA expression (0 replies)
Recently I was thinking about my RNA project and wishing that I could express RNA in bacteria as is typically done for recombinant proteins. I looked at the July issue of Nature Methods to see a paper describing exactly the technology I was imagining. The authors created plasmids which allow the fusion of a target RNA sequence to a tRNA scaffold which is authenically processed by the cellular machinery and protected from degradation by the intrinsic stability of the tRNA. The potential benefits of this technology for NMR of RNA...
nmrlearner
News from other NMR forums
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08-21-2010 03:29 PM
[Nature network NMR forum] Journal club: structure of the ternary Prp31:15.5K:U4 snRNA complex (1 reply)
Journal club: structure of the ternary Prp31:15.5K:U4 snRNA complex (1 reply)
I would like to start the “journal club” section of the NMR forum by presenting my favorite paper from the recent literature.
The paper (in this weeks issue of Science) is, in my opinion at least, a perfect example of the ability of NMR to contribute to the structural analysis of a challenging RNA-protein complex
I chose this high-impact paper because the combination of biochemistry, NMR, and crystallography on a ternary complex is how I would like to tackle a challenging project that I am...
Journal club: structural biology of HIV infection (0 replies)
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