[Question from NMRWiki Q&A forum] 1,n-ADEQUATE setup

[nmrlearner]

1,n-ADEQUATE setup

I need to measure the 4-bond coupling into a group of unassigned quaternary carbons.I would like to use the 1,n-ADEQUATE but it is commonly displayed as a DQ format which is not comparable to the standard 2D axis.

I read about a refocused version of the 1,1-ADEQUATE. This refocusing makes it possible to directly compare the spectra of traditional non-DQ formats so I was wondering if the same refocusing period could be used in the 1,n experiment?

If not, how do you optimize the indirect DQ formated axis (in Bruker SW and O2P) of the 1,n-ADEQUATE experiment if you know the expected range of your signals from a standard HMBC?



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