The tremendous polarization enhancement afforded by dissolution dynamic nuclear polarization (DNP) can be taken advantage of to perform molecular and metabolic imaging. Following the injection of molecules that are hyperpolarized via dissolution DNP, real-time measurements of their biodistribution and metabolic conversion can be recorded. This technology therefore provides a unique and invaluable tool for probing cellular metabolism in vivo in a noninvasive manner. It gives the opportunity to follow and evaluate disease progression and treatment response without requiring ex vivo destructive tissue assays. Seven sites across the globe are currently performing human studies using hyperpolarized 13C-pyruvate, and several other institutions are on the brink of being ready to inject their first patients. The most promising fields of application of this technology are in oncology and cardiology, and the aim of this article is to provide an overview of some of the current in vivo preclinical and clinical applications of hyperpolarized 13C magnetic resonance spectroscopy and imaging. Some new approaches and potential future developments to improve the hyperpolarized 13C technology are also presented and discussed.
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates #DNPNMR
From The DNP-NMR Blog:
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13C MR with Photosensitive Metabolic Substrates #DNPNMR
Marco-Rius, Irene, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, and Arnaud Comment. “Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates.” Journal of the American Chemical Society 140, no. 43 (October 31, 2018): 14455–63.
https://doi.org/10.1021/jacs.8b09326.
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11-25-2018 06:02 AM
A radiofrequency system for in vivo hyperpolarized (13) C MRS experiments in mice with a 3T MRI clinical scanner
From The DNP-NMR Blog:
A radiofrequency system for in vivo hyperpolarized (13) C MRS experiments in mice with a 3T MRI clinical scanner
Giovannetti, G., et al., A radiofrequency system for in vivo hyperpolarized (13) C MRS experiments in mice with a 3T MRI clinical scanner. Scanning, 2016. 38(6): p. 710-719.
https://www.ncbi.nlm.nih.gov/pubmed/27059822
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05-18-2018 05:21 PM
Hyperpolarized [1,4-(13)C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging
From The DNP-NMR Blog:
Hyperpolarized -diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging
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Billingsley, K.L., et al., Hyperpolarized -diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. NMR Biomed, 2014. 27(3): p. 356-62.
https://www.ncbi.nlm.nih.gov/pubmed/24421249
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02-10-2017 04:19 PM
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
From The DNP-NMR Blog:
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
Keshari, K.R., et al., Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc. Nat. Aca. Sci. USA, 2011. 108(46): p. 18606-18611.
http://www.pnas.org/content/108/46/18606.abstract
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07-23-2014 11:25 PM
Postdoc position (in vivo hyperpolarized 13C MR)
From The DNP-NMR Blog:
Postdoc position (in vivo hyperpolarized 13C MR)
The University of Maryland School of Medicine is expanding its molecular imaging and interventional research capabilities with the addition of a Dynamic Nuclear Polarizer and High-Intensity Focused Ultrasound as part of the recently established Center for Integration of Metabolic Imaging and Therapeutics (CIMIT). This expansion is aimed to facilitate both basic science and clinical research by exploring novel molecular imaging agent based technologies for screening, early detection, and real-time...
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11-21-2013 01:14 AM
In vivo magnetic resonance imaging of hyperpolarized silicon particles
From The DNP-NMR Blog:
In vivo magnetic resonance imaging of hyperpolarized silicon particles
Cassidy, M.C., et al., In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nano, 2013. 8(5): p. 363-368.
http://dx.doi.org/10.1038/nnano.2013.65
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08-29-2013 01:27 AM
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
From the The DNP-NMR Blog:
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
Nelson, S.J., et al., Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J. Magn. Reson., 2013. 229(0): p. 187-197.
http://dx.doi.org/10.1016/j.jmr.2013.02.003
In Vivo Hyperpolarized 13C MRS and MRI Applications #DNPNMR
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