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Pinter, G. and H. Schwalbe, Unprecedented Carbon Signal Enhancement in Liquid-State NMR Spectroscopy. Angew Chem Int Ed Engl, 2017. 56(29): p. 8332-8334.
We shall overcome: As a result of efforts to overcome the sensitivity challenge of liquid-state NMR spectroscopy, a thousand-fold signal enhancement was achieved by dynamic nuclear polarization (DNP) for 13 C signals at high magnetic field (3.4 T) and room temperature, thereby exceeding the predicted limitations of high-field liquid-state in situ DNP.
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A DNP-supported solid-state NMR study of carbon species in fluid catalytic cracking catalysts #DNPNMR
From The DNP-NMR Blog:
A DNP-supported solid-state NMR study of carbon species in fluid catalytic cracking catalysts #DNPNMR
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Mance, D., et al., A DNP-supported solid-state NMR study of carbon species in fluid catalytic cracking catalysts. Chem Commun (Camb), 2017. 53(28): p. 3933-3936.
https://www.ncbi.nlm.nih.gov/pubmed/28327736
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06-23-2017 04:36 PM
[NMR paper] Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Mol Pharm. 2017 Jun 14;:
Authors: Kheddo P, Bramham JE, Dearman RJ, Uddin S, van der Walle CF, Golovanov AP
Abstract
Liquid-liquid phase separation (LLPS) of monoclonal antibody (mAb) formulations involves spontaneous separation into dense...
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06-15-2017 03:37 PM
T1 - Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags #DNPNMR
From The DNP-NMR Blog:
T1 - Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags #DNPNMR
Rivkah Rogawski, Ivan V. Sergeyev, Yongjun Li, M. Francesca Ottaviani, Virginia Cornish, and Ann E. McDermott The Journal of Physical Chemistry B 2017 121 (6), 1169-1175
http://dx.doi.org/10.1021/acs.jpcb.6b09021
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05-19-2017 04:40 PM
Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags #DNPNMR
From The DNP-NMR Blog:
Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags #DNPNMR
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Rogawski, R., et al., Dynamic Nuclear Polarization Signal Enhancement with High-Affinity Biradical Tags. The Journal of Physical Chemistry B, 2017. 121(6): p. 1169-1175.
http://dx.doi.org/10.1021/acs.jpcb.6b09021
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03-20-2017 05:16 PM
500-fold enhancement of in situ (13)C liquid state NMR using gyrotron-driven temperature-jump DNP #DNPNMR
From The DNP-NMR Blog:
500-fold enhancement of in situ (13)C liquid state NMR using gyrotron-driven temperature-jump DNP #DNPNMR
Yoon, D., et al., 500-fold enhancement of in situ (13)C liquid state NMR using gyrotron-driven temperature-jump DNP. J Magn Reson, 2016. 270: p. 142-6.
http://www.ncbi.nlm.nih.gov/pubmed/27490302
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09-02-2016 11:54 PM
[NMR paper] Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins.
Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins.
Related Articles Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins.
J Biomol NMR. 2015 Oct 22;
Authors: Ward ME, Ritz E, Ahmed MA, Bamm VV, Harauz G, Brown LS, Ladizhansky V
Abstract
Direct proton detection is becoming an increasingly popular method for enhancing sensitivity in solid-state nuclear magnetic resonance spectroscopy. Generally, these experiments...
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10-24-2015 06:43 PM
Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins
Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins
Abstract
Direct proton detection is becoming an increasingly popular method for enhancing sensitivity in solid-state nuclear magnetic resonance spectroscopy. Generally, these experiments require extensive deuteration of the protein, fast magic angle spinning (MAS), or a combination of both. Here, we implement direct proton detection to selectively observe the mobile entities in fully-protonated membrane proteins at moderate MAS frequencies. We...
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10-23-2015 02:14 PM
Signal enhancement for the sensitivity-limited solid state NMR experiments using a continuous, non-uniform acquisition scheme.
Signal enhancement for the sensitivity-limited solid state NMR experiments using a continuous, non-uniform acquisition scheme.
Signal enhancement for the sensitivity-limited solid state NMR experiments using a continuous, non-uniform acquisition scheme.
J Magn Reson. 2011 Aug 30;
Authors: Qiang W
Abstract
We describe a sampling scheme for the two-dimensional (2D) solid state NMR experiments, which can be readily applied to the sensitivity-limited samples. The sampling scheme utilizes continuous, non-uniform sampling profile for the...
Unprecedented Carbon Signal Enhancement in Liquid-State NMR Spectroscopy #DNPNMR
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