Kumar, Akshay, Hippolyte Durand, Elisa Zeno, Cyril Balsollier, Bastien Watbled, Cecile Sillard, Sébastien Fort, et al. “The Surface Chemistry of a Nanocellulose Drug Carrier Unravelled by MAS-DNP.” Chemical Science, 2020, 10.1039.C9SC06312A.
Cellulose nanofibrils (CNF) are renewable bio-based materials with high specific area, which makes them ideal candidates for multiple emerging applications including for instance on-demand drug release. However, in-depth chemical and structural characterization of the CNF surface chemistry is still an open challenge, especially for low weight percentage of functionalization. This currently prevents the development of efficient, cost-effective and reproducible green synthetic routes and thus the widespread development of targeted and responsive drug-delivery CNF carriers. We show in this work how we use dynamic nuclear polarization (DNP) to overcome the sensitivity limitation of conventional solid-state NMR and gain insight into the surface chemistry of drug-functionalized TEMPO-oxidized cellulose nanofibrils. The DNP enhanced-NMR data can report unambiguously on the presence of trace amounts of TEMPO moieties and depolymerized cellulosic units in the starting material, as well as coupling agents on the CNFs surface (used in the heterogeneous reaction). This enables a precise estimation of the drug loading while differentiating adsorption from covalent bonding (~1 wt% in our case) as opposed to other analytical techniques such as elemental analysis and conductometric titration that can neither detect the presence of coupling agents, nor differentiate unambiguously between adsorption and grafting. The approach, which does not rely on the use of 13C/15N enriched compounds, will be key to further develop efficient surface chemistry routes and has direct implication for the development of drug delivery applications both in terms of safety and dosage.
DNP in Materials Science: Touching the Surface #DNPNMR
From The DNP-NMR Blog:
DNP in Materials Science: Touching the Surface #DNPNMR
Berruyer, Pierrick, Lyndon Emsley, and Anne Lesage. “DNP in Materials Science: Touching the Surface,” 7:12, 2018.
https://doi.org/10.1002/9780470034590.emrstm1554.
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05-22-2020 03:58 PM
Surface chemical heterogeneity modulates silica surface hydration #DNPNMR #ODNP
From The DNP-NMR Blog:
Surface chemical heterogeneity modulates silica surface hydration #DNPNMR #ODNP
Schrader, Alex M., Jacob I. Monroe, Ryan Sheil, Howard A. Dobbs, Timothy J. Keller, Yuanxin Li, Sheetal Jain, M. Scott Shell, Jacob N. Israelachvili, and Songi Han. “Surface Chemical Heterogeneity Modulates Silica Surface Hydration.” Proceedings of the National Academy of Sciences 115, no. 12 (March 20, 2018): 2890–95.
https://doi.org/10.1073/pnas.1722263115.
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03-24-2019 10:41 PM
[ASAP] The “Recognition Helix” of the Type II Acyl Carrier Protein (ACP) Utilizes a “Ubiquitin Interacting Motif (UIM)”-like Surface To Bind Its Partners
The “Recognition Helix” of the Type II Acyl Carrier Protein (ACP) Utilizes a “Ubiquitin Interacting Motif (UIM)”-like Surface To Bind Its Partners
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00220/20180619/images/medium/bi-2018-00220e_0010.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00220
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/4D50TNanhmQ
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06-19-2018 08:46 PM
Surface-selective direct 17O DNP NMR of CeO2 nanoparticles #DNPNMR
From The DNP-NMR Blog:
Surface-selective direct 17O DNP NMR of CeO2 nanoparticles #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Hope, M.A., et al., Surface-selective direct 17O DNP NMR of CeO2 nanoparticles. Chem Commun (Camb), 2017. 53(13): p. 2142-2145.
https://www.ncbi.nlm.nih.gov/pubmed/28134945
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06-05-2017 03:59 PM
Surface-selective direct 17O DNP NMR of CeO2 nanoparticles #DNPNMR
From The DNP-NMR Blog:
Surface-selective direct 17O DNP NMR of CeO2 nanoparticles #DNPNMR
Michael A. Hope et. al, Chem. Commun., 2017,53, 2142-2145
http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C6CC10145C
nmrlearner
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05-18-2017 02:05 AM
Acyl Carrier Protein Cyanylation Delivers a KetoacylSynthase–Carrier Protein Cross-Link
Acyl Carrier Protein Cyanylation Delivers a KetoacylSynthase–Carrier Protein Cross-Link
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00219/20170508/images/medium/bi-2017-00219v_0003.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00219
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
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