Chen, Hsueh-Ying, and Robert Tycko. “Slice Selection in Low-Temperature, DNP-Enhanced Magnetic Resonance Imaging by Lee-Goldburg Spin-Locking and Phase Modulation.” Journal of Magnetic Resonance 313 (April 2020): 106715.
Large enhancements in nuclear magnetic resonance (NMR) signals provided by dynamic nuclear polarization (DNP) at low temperatures have the potential to enable inductively-detected 1H magnetic resonance imaging (MRI) with isotropic spatial resolution on the order of one micron, especially when low temperatures and DNP are combined with microcoils, three-dimensional (3D) phase encoding of image information, pulsed spin locking during NMR signal detection, and homonuclear dipolar decoupling by Lee-Goldburg (LG) irradiation or similar methods. However, the relatively slow build-up of nuclear magnetization under DNP leads to very long acquisition times for high-resolution 3D images unless the sample volume or field of view (FOV) is restricted. We have therefore developed a method for slice selection in low-temperature, DNP-enhanced MRI that limits the FOV to about 50 ?m in one or more dimensions. This method uses small-amplitude phase modulation of LG irradiation in the presence of a strong magnetic field gradient to invert spin-locked 1H magnetization in the selected slice. Experimental results are reported, including effects of radio-frequency field inhomogeneity, variations in the amplitude of phase modulation, and shaped phase modulation.
Electron spin resonance studies on deuterated nitroxyl spin probes used in Overhauser-enhanced magnetic resonance imaging #DNPNMR #ODNP
From The DNP-NMR Blog:
Electron spin resonance studies on deuterated nitroxyl spin probes used in Overhauser-enhanced magnetic resonance imaging #DNPNMR #ODNP
Jebaraj, D. David, Hideo Utsumi, and A. Milton Franklin Benial. “Electron Spin Resonance Studies on Deuterated Nitroxyl Spin Probes Used in Overhauser-Enhanced Magnetic Resonance Imaging.” Magnetic Resonance in Chemistry 55, no. 8 (2017): 700–705.
https://doi.org/10.1002/mrc.4576.
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06-23-2018 12:47 AM
ESR line width and line shape dependence of Overhauser-enhanced magnetic resonance imaging #DNPNMR
From The DNP-NMR Blog:
ESR line width and line shape dependence of Overhauser-enhanced magnetic resonance imaging #DNPNMR
Meenakumari, V., Hideo Utsumi, A. Jawahar, and A. Milton Franklin Benial. “ESR Line Width and Line Shape Dependence of Overhauser-Enhanced Magnetic Resonance Imaging.” Magnetic Resonance in Chemistry 54, no. 11 (2016): 874–79.
https://doi.org/10.1002/mrc.4489
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06-13-2018 05:09 PM
Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution
From The DNP-NMR Blog:
Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution
Chen, H.-Y. and R. Tycko, Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution. Journal of Magnetic Resonance, 2018. 287: p. 47-55.
http://www.sciencedirect.com/science/article/pii/S1090780717303087
Dynamic nuclear polarization studies of nitroxyl spin probes in agarose gel using Overhauser-enhanced magnetic resonance imaging
From The DNP-NMR Blog:
Dynamic nuclear polarization studies of nitroxyl spin probes in agarose gel using Overhauser-enhanced magnetic resonance imaging
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Meenakumari, V., et al., Dynamic nuclear polarization studies of nitroxyl spin probes in agarose gel using Overhauser-enhanced magnetic resonance imaging. Magn Reson Chem, 2017. 55(11): p. 1022-1028.
https://www.ncbi.nlm.nih.gov/pubmed/28599057
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10-21-2017 04:46 AM
Simultaneous and spectroscopic redox molecular imaging of multiple free radical intermediates using dynamic nuclear polarization-magnetic resonance imaging #DNPNMR
From The DNP-NMR Blog:
Simultaneous and spectroscopic redox molecular imaging of multiple free radical intermediates using dynamic nuclear polarization-magnetic resonance imaging #DNPNMR
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Hyodo, F., et al., Simultaneous and spectroscopic redox molecular imaging of multiple free radical intermediates using dynamic nuclear polarization-magnetic resonance imaging. Anal Chem, 2014. 86(15): p. 7234-8.
https://www.ncbi.nlm.nih.gov/pubmed/25036767
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08-17-2017 12:56 AM
Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR
From The DNP-NMR Blog:
Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR
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Lee, Y., Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions. Applied Spectroscopy Reviews, 2015. 51(3): p. 210-226.
https://doi.org/10.1080/05704928.2015.1116078
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12-30-2016 04:53 PM
[U. of Ottawa NMR Facility Blog] Sample Slice Selection in NMR Spectroscopy
Sample Slice Selection in NMR Spectroscopy
In MRI, field gradients are used routinely for slice selection while imaging a sample. Gradients are also finding applications in high resolution NMR spectroscopy employing fast data collection techniques using parallel data acquisition for multiple slices of the same sample. A good example of this can be found in Carlos' BLOG (and the references therein). The slice selection is accomplished by turning on a linear field gradient across the sample while applying an excitation pulse. While the gradient is on, the frequencies of each of the NMR...
Slice selection in low-temperature, DNP-enhanced magnetic resonance imaging by Lee-Goldburg spin-locking and phase modulation #DNPNMR
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