PURPOSE: To study hyperpolarized water as an angiography and perfusion tracer in a large animal model. METHODS: Protons dissolved in deuterium oxide (D2 O) were hyperpolarized in a SPINlab dissolution dynamic nuclear polarization (dDNP) polarizer and subsequently investigated in vivo in a pig model at 3 Tesla (T). Approximately 15 mL of hyperpolarized water was injected in the renal artery by hand over 4-5 s. RESULTS: A liquid state polarization of 5.3 +/- 0.9% of 3.8 M protons in 15 mL of deuterium oxide was achieved with a T1 of 24 +/- 1 s. This allowed injection through an arterial catheter into the renal artery and subsequently high-contrast imaging of the entire kidney parenchyma over several seconds. The dynamic images allow quantification of tissue perfusion, with a mean cortical perfusion of 504 +/- 123 mL/100 mL/min. CONCLUSION: Hyperpolarized water MR imaging was successfully demonstrated as a renal angiography and perfusion method. Quantitative perfusion maps of the kidney were obtained in agreement with literature and control experiments with gadolinium contrast. Magn Reson Med, 2016. (c) 2016 International Society for Magnetic Resonance in Medicine.
Hyperpolarized Water to Study Protein–Ligand Interactions
From The DNP-NMR Blog:
Hyperpolarized Water to Study Protein–Ligand Interactions
Chappuis, Q., et al., Hyperpolarized Water to Study Protein–Ligand Interactions. The Journal of Physical Chemistry Letters, 2015. 6(9): p. 1674-1678.
http://dx.doi.org/10.1021/acs.jpclett.5b00403
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06-06-2015 12:01 PM
Sub-second proton imaging of 13C hyperpolarized contrast agents in water
From The DNP-NMR Blog:
Sub-second proton imaging of 13C hyperpolarized contrast agents in water
Truong, M.L., et al., Sub-second proton imaging of 13C hyperpolarized contrast agents in water. Contrast Media Mol Imaging, 2014. 9(5): p. 333-41.
http://www.ncbi.nlm.nih.gov/pubmed/24753438
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03-11-2015 09:59 PM
On the Potential of Hyperpolarized Water in Biomolecular NMR Studies
From The DNP-NMR Blog:
On the Potential of Hyperpolarized Water in Biomolecular NMR Studies
Harris, T., O. Szekely, and L. Frydman, On the Potential of Hyperpolarized Water in Biomolecular NMR Studies. The Journal of Physical Chemistry B, 2014. 118(12): p. 3281-3290.
http://dx.doi.org/10.1021/jp4102916
Renal MR angiography and perfusion in the pig using hyperpolarized water
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