Giovannetti, G., et al., A radiofrequency system for in vivo hyperpolarized (13) C MRS experiments in mice with a 3T MRI clinical scanner. Scanning, 2016. 38(6): p. 710-719.
Hyperpolarized carbon-13 magnetic resonance spectroscopy (MRS) is a powerful tool to explore tissue metabolic state, by permitting the study of intermediary metabolism of biomolecules in vivo. However, a number of technological problems still limit this technology and need innovative solutions. In particular, the low molar concentration of derivate metabolites give rise to low signal-to-noise ratio (SNR), which makes the design and development of dedicated radiofrequency (RF) coils a fundamental task. In this article, the authors describe the simulation and the design of a RF coils configuration for MR experiments in mice, constituted by a (1) H whole body volume RF coil for imaging and a (13) C single circular loop surface RF coil for performing (13) C acquisitions. After the building, the RF system was employed in an in vivo experiment in a mouse injected with hyperpolarized [1-(13) C]pyruvate by using a 3 T clinical MR scanner. SCANNING 38:710-719, 2016. (c) 2016 Wiley Periodicals, Inc.
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Hyperpolarized [1,4-(13)C]-diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging
From The DNP-NMR Blog:
Hyperpolarized -diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging
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Billingsley, K.L., et al., Hyperpolarized -diethylsuccinate: a potential DNP substrate for in vivo metabolic imaging. NMR Biomed, 2014. 27(3): p. 356-62.
https://www.ncbi.nlm.nih.gov/pubmed/24421249
Simultaneous hyperpolarized (13)C-pyruvate MRI and (18)F-FDG-PET in cancer (hyperPET): feasibility of a new imaging concept using a clinical PET/MRI scanner
From The DNP-NMR Blog:
Simultaneous hyperpolarized (13)C-pyruvate MRI and (18)F-FDG-PET in cancer (hyperPET): feasibility of a new imaging concept using a clinical PET/MRI scanner
Gutte, H., et al., Simultaneous hyperpolarized (13)C-pyruvate MRI and (18)F-FDG-PET in cancer (hyperPET): feasibility of a new imaging concept using a clinical PET/MRI scanner. American Journal of Nuclear Medicine and Molecular Imaging, 2015. 5(1): p. 38-45.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299777/
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05-14-2015 04:52 AM
Transmit-Only/Receive-Only Radiofrequency System for Hyperpolarized 13C MRS Cardiac Metabolism Studies in Pigs
From The DNP-NMR Blog:
Transmit-Only/Receive-Only Radiofrequency System for Hyperpolarized 13C MRS Cardiac Metabolism Studies in Pigs
Giovannetti, G., et al., Transmit-Only/Receive-Only Radiofrequency System for Hyperpolarized 13C MRS Cardiac Metabolism Studies in Pigs. Appl. Magn. Reson., 2013. 44(10): p. 1125-1138.
http://dx.doi.org/10.1007/s00723-013-0477-3
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11-21-2013 01:14 AM
Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research
From The DNP-NMR Blog:
Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research
Kurhanewicz, J., et al., Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia, 2011. 13(2): p. 81-97.
http://www.ncbi.nlm.nih.gov/pubmed/21403835
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11-21-2013 01:14 AM
Postdoc position (in vivo hyperpolarized 13C MR)
From The DNP-NMR Blog:
Postdoc position (in vivo hyperpolarized 13C MR)
The University of Maryland School of Medicine is expanding its molecular imaging and interventional research capabilities with the addition of a Dynamic Nuclear Polarizer and High-Intensity Focused Ultrasound as part of the recently established Center for Integration of Metabolic Imaging and Therapeutics (CIMIT). This expansion is aimed to facilitate both basic science and clinical research by exploring novel molecular imaging agent based technologies for screening, early detection, and real-time...
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11-21-2013 01:14 AM
In vivo magnetic resonance imaging of hyperpolarized silicon particles
From The DNP-NMR Blog:
In vivo magnetic resonance imaging of hyperpolarized silicon particles
Cassidy, M.C., et al., In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nano, 2013. 8(5): p. 363-368.
http://dx.doi.org/10.1038/nnano.2013.65
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08-29-2013 01:27 AM
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
From the The DNP-NMR Blog:
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
Nelson, S.J., et al., Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J. Magn. Reson., 2013. 229(0): p. 187-197.
http://dx.doi.org/10.1016/j.jmr.2013.02.003
A radiofrequency system for in vivo hyperpolarized (13) C MRS experiments in mice with a 3T MRI clinical scanner
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