Perras, F.A., T. Kobayashi, and M. Pruski, PRESTO polarization transfer to quadrupolar nuclei: implications for dynamic nuclear polarization. Phys Chem Chem Phys, 2015. 17(35): p. 22616-22.
We show both experimentally and numerically on a series of model systems that in experiments involving transfer of magnetization from (1)H to the quadrupolar nuclei under magic-angle-spinning (MAS), the PRESTO technique consistently outperforms traditionally used cross polarization (CP), affording more quantitative intensities, improved lineshapes, better overall sensitivity, and straightforward optimization. This advantage derives from the fact that PRESTO circumvents the convoluted and uncooperative spin dynamics during the CP transfer under MAS, by replacing the spin-locking of quadrupolar nuclei with a single central transition selective 90 degrees pulse and using a symmetry-based recoupling sequence in the (1)H channel. This is of particular importance in the context of dynamic nuclear polarization (DNP) NMR of quadrupolar nuclei, where the efficient transfer of enhanced (1)H polarization is desired to obtain the highest sensitivity.
Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery
From The DNP-NMR Blog:
Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery
Min, H., G. Sekar, and C. Hilty, Polarization Transfer from Ligands Hyperpolarized by Dissolution Dynamic Nuclear Polarization for Screening in Drug Discovery. ChemMedChem, 2015. 10(9): p. 1559-63.
http://www.ncbi.nlm.nih.gov/pubmed/26315550
nmrlearner
News from NMR blogs
0
10-05-2015 07:08 PM
Self-assembled trityl radical capsules--implications for dynamic nuclear polarization
From The DNP-NMR Blog:
Self-assembled trityl radical capsules--implications for dynamic nuclear polarization
Marin-Montesinos, I., et al., Self-assembled trityl radical capsules--implications for dynamic nuclear polarization. Phys Chem Chem Phys, 2015. 17(8): p. 5785-94.
http://www.ncbi.nlm.nih.gov/pubmed/25626422
nmrlearner
News from NMR blogs
0
04-29-2015 03:49 PM
Cross polarization from (1)H to quadrupolar (6)Li nuclei for dissolution DNP
From The DNP-NMR Blog:
Cross polarization from (1)H to quadrupolar (6)Li nuclei for dissolution DNP
Perez Linde, A.J., et al., Cross polarization from (1)H to quadrupolar (6)Li nuclei for dissolution DNP. Phys Chem Chem Phys, 2014. 16(45): p. 24813-7.
http://www.ncbi.nlm.nih.gov/pubmed/25319311
nmrlearner
News from NMR blogs
0
11-05-2014 04:04 PM
Dynamic Nuclear Polarization NMR of Low-? Nuclei: Structural Insights into Hydrated Yttrium-Doped BaZrO3
From The DNP-NMR Blog:
Dynamic Nuclear Polarization NMR of Low-? Nuclei: Structural Insights into Hydrated Yttrium-Doped BaZrO3
Blanc, F., et al., Dynamic Nuclear Polarization NMR of Low-? Nuclei: Structural Insights into Hydrated Yttrium-Doped BaZrO3. The Journal of Physical Chemistry Letters, 2014: p. 2431-2436.
http://dx.doi.org/10.1021/jz5007669
nmrlearner
News from NMR blogs
0
07-04-2014 08:28 PM
[NMR paper] Efficient polarization transfer between spin-1/2 and (14)N nuclei in solid-state MAS NMR spectroscopy.
Efficient polarization transfer between spin-1/2 and (14)N nuclei in solid-state MAS NMR spectroscopy.
Related Articles Efficient polarization transfer between spin-1/2 and (14)N nuclei in solid-state MAS NMR spectroscopy.
J Magn Reson. 2014 May 9;244C:85-89
Authors: Basse K, Jain SK, Bakharev O, Nielsen NC
Abstract
Polarization transfer between spin-1/2 nuclei and quadrupolar spin-1 nuclei such as (14)N in solid-state NMR is severely challenged by the typical presence of large quadrupole coupling interactions. This has...
nmrlearner
Journal club
0
06-02-2014 10:02 PM
[NMR paper] Low-power polarization transfer between deuterons and spin-1/2 nuclei using adiabatic (RESPIRATION)CP in solid-state NMR.
Low-power polarization transfer between deuterons and spin-1/2 nuclei using adiabatic (RESPIRATION)CP in solid-state NMR.
Related Articles Low-power polarization transfer between deuterons and spin-1/2 nuclei using adiabatic (RESPIRATION)CP in solid-state NMR.
Phys Chem Chem Phys. 2014 Jan 13;
Authors: Jain SK, Nielsen AB, Hiller M, Handel L, Ernst M, Oschkinat H, Akbey U, Nielsen NC
Abstract
Establishing high-resolution structures of biological macromolecules in heterogeneous environments by MAS solid-state NMR is an important...
Enhanced Solid-State NMR Correlation Spectroscopy of Quadrupolar Nuclei Using Dynamic Nuclear Polarization
Enhanced Solid-State NMR Correlation Spectroscopy of Quadrupolar Nuclei Using Dynamic Nuclear Polarization
Daniel Lee, Hiroki Takahashi, Aany S. L. Thankamony, Jean-Philippe Dacquin, Michel Bardet, Olivier Lafon and Gae?l De Pae?pe
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja307755t/aop/images/medium/ja-2012-07755t_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja307755t
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/NcXbDBD9aBc
PRESTO polarization transfer to quadrupolar nuclei: implications for dynamic nuclear polarization
Linear Mode
