On the present and future of dissolution-DNP

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On the present and future of dissolution-DNP

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NMR processing:

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NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

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Fragment-based:

Rosetta-NMR (Robetta)

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GeNMR

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Amber

Structure from chemical shifts:

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Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

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NOEs, other restraints:

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V-NMR

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Backbone S2

Methyl S2

B-factor

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Shiftx2

Sparta+

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CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

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Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

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Protein disorder:

DisMeta

Protein solubility:

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04-22-2016, 08:45 PM

nmrlearner

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On the present and future of dissolution-DNP

From The DNP-NMR Blog:

On the present and future of dissolution-DNP

Ardenkjaer-Larsen, J.H., On the present and future of dissolution-DNP. J Magn Reson, 2016. 264: p. 3-12.

http://www.ncbi.nlm.nih.gov/pubmed/26920825

Dissolution-DNP is a method to create solutions of molecules with nuclear spin polarization close to unity. The many orders of magnitude signal enhancement have enabled many new applications, in particular in vivo MR metabolic imaging. The method relies on solid state dynamic nuclear polarization at low temperature followed by a dissolution to produce the room temperature solution of highly polarized spins. This work describes the present and future of dissolution-DNP in the mind of the author. The article describes some of the current trends in the field as well as outlines some of the areas where new ideas will make an impact. Most certainly, the future will take unpredicted directions, but hopefully the thoughts presented here will stimulate new ideas that can further advance the field.

Go to The DNP-NMR Blog for more info.

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