Nuclear magnetic resonance (NMR) is one of the most powerful analytical techniques currently available, with applications in fields ranging from synthetic chemistry to clinical diagnosis. Due to the size and cost of high-field spectrometers, NMR is generally considered to be ill-suited for industrial environments and field work. This conventional wisdom is currently being challenged through the development of NMR systems that are smaller, cheaper, more robust and portable. Despite remarkable progress in this area, potential applications are often limited by low sensitivity. Hyperpolarisation techniques have the potential to overcome this limitation and revolutionise the use of compact NMR. This review describes the state-of-the-art in NMR hyperpolarisation and presents promising examples of its application to compact NMR. Both the benefits and challenges associated with the different hyperpolarisation approaches are discussed and applications where these technologies have the potential to make a significant impact are highlighted.
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PDRA opportunities to work in hyperpolarisation.
From The DNP-NMR Blog:
PDRA opportunities to work in hyperpolarisation.
From the Ampere Magnetic Resonance List
We have 5 positions available to work on developing parahydrogen derived hyperpolarisation methods in the York Centre for Hyperpolarisation in Magnetic Resonance (http://www.york.ac.uk/chym/).
[Stan NMR blog] Compact permanent magnets for time-domain NMR
Compact permanent magnets for time-domain NMR
Compact MR-quality permanent magnets available off the shelf up to 0.5 T
Source: Stan blog library
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11-23-2010 07:10 AM
[NMR paper] A compact monomeric intermediate identified by NMR in the denaturation of dimeric tri
A compact monomeric intermediate identified by NMR in the denaturation of dimeric triose phosphate isomerase.
Related Articles A compact monomeric intermediate identified by NMR in the denaturation of dimeric triose phosphate isomerase.
J Mol Biol. 2000 Jun 30;300(1):11-6
Authors: Morgan CJ, Wilkins DK, Smith LJ, Kawata Y, Dobson CM
The denaturation of triose phosphate isomerase (TIM) from Saccharomyces cerevisiae by guanidine hydrochlorids at pH 7.2 has been monitored by NMR spectroscopy in conjunction with optical spectroscopy. In the...
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11-18-2010 09:15 PM
[NMR paper] Design and NMR analyses of compact, independently folded BBA motifs.
Design and NMR analyses of compact, independently folded BBA motifs.
Related Articles Design and NMR analyses of compact, independently folded BBA motifs.
Fold Des. 1998;3(2):95-103
Authors: Struthers M, Ottesen JJ, Imperiali B
BACKGROUND: Small folded polypeptide motifs represented highly simplified systems for theoretical and experimental studies on protein structure and folding. We have recently reported the design and characterization of a metal-ion-independent 23-residue peptide with a beta beta alpha structure (BBA1), based on the zinc...
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11-17-2010 11:06 PM
[Stan NMR blog] Compact permanent magnets for time-domain NMR
Compact permanent magnets for time-domain NMR
Compact MR-quality permanent magnets available off the shelf up to 0.5 T
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Perspectives for hyperpolarisation in compact NMR
Linear Mode
