This mini-*review considers the scientific and historical development of the constant 1.26T2, which represents the acquisition time for which the signal-*to-*noise ratio of a decaying exponential (with time constant T2) is a maximum in the presence of thermal noise. While first reported in 1977, interest in this result greatly increased after about the year 2000, when it began to influence thinking in nonuniform sampling, sensitivity, and pulse sequence design. Overall, 1.26T2 has become a lens through which to view the evolution of NMR data acquisition and processing. An enduring lesson of the 1.26T2 story is the value of describing and analyzing the properties of magnetic resonance signals in the time domain prior to any further spectral analysis and processing, a concept which is at the core of many modern analytic techniques.
[NMR paper] Biomolecular NMR: Past and future.
Biomolecular NMR: Past and future.
Related Articles Biomolecular NMR: Past and future.
Arch Biochem Biophys. 2017 May 08;:
Authors: Markley JL, Westler WM
Abstract
The editors of this special volume suggested this topic, presumably because of the perspective lent by our combined >90-year association with biomolecular NMR. What follows is our personal experience with the evolution of the field, which we hope will illustrate the trajectory of change over the years. As for the future, one can confidently predict that it will involve...
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05-13-2017 02:08 PM
On the present and future of dissolution-DNP
From The DNP-NMR Blog:
On the present and future of dissolution-DNP
Ardenkjaer-Larsen, J.H., On the present and future of dissolution-DNP. J Magn Reson, 2016. 264: p. 3-12.
http://www.ncbi.nlm.nih.gov/pubmed/26920825
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04-22-2016 08:45 PM
Past and Future Solid-State NMR Spectroscopy Studies at the Convergence Point between Biology and Materials Research
From The DNP-NMR Blog:
Past and Future Solid-State NMR Spectroscopy Studies at the Convergence Point between Biology and Materials Research
With DNP becoming an important technique in the material science community it is good to take a look every now and then at the progress that the field of solid-state NMR spectroscopy is making in the area of material science.
Goobes, G., Past and Future Solid-State NMR Spectroscopy Studies at the Convergence Point between Biology and Materials Research. Israel Journal of Chemistry, 2014. 54(1-2): p. 113-124.
...
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08-01-2014 06:21 PM
[NMR paper] Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
Related Articles Present and future of NMR for RNA-protein complexes: A perspective of integrated structural biology.
J Magn Reson. 2014 Apr;241:126-36
Authors: Carlomagno T
Abstract
Nucleic acids are gaining enormous importance as key molecules in almost all biological processes. Most nucleic acids do not act in isolation but are generally associated with proteins to form high-molecular-weight nucleoprotein complexes. In this perspective...
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03-25-2014 11:49 AM
[NMR paper] Chemical exchange in biomacromolecules: Past, present, and future
Chemical exchange in biomacromolecules: Past, present, and future
Publication date: April 2014
Source:Journal of Magnetic Resonance, Volume 241</br>
Author(s): Arthur G. Palmer III</br>
The perspective reviews quantitative investigations of chemical exchange phenomena in proteins and other biological macromolecules using NMR spectroscopy, particularly relaxation dispersion methods. The emphasis is on techniques and applications that quantify the populations, interconversion kinetics, and structural features of sparsely populated conformational states in equilibrium...
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03-22-2014 01:28 AM
Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology
Present and future of NMR for RNA–protein complexes: A perspective of integrated structural biology
Publication date: April 2014
Source:Journal of Magnetic Resonance, Volume 241</br>
Author(s): Teresa Carlomagno</br>
Nucleic acids are gaining enormous importance as key molecules in almost all biological processes. Most nucleic acids do not act in isolation but are generally associated with proteins to form high-molecular-weight nucleoprotein complexes. In this perspective article I focus on the structural studies of supra-molecular ribonucleoprotein (RNP) assemblies...
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03-21-2014 12:52 AM
[NMR paper] The present and future of solution NMR in investigating the structure and dynamics of channels and transporters.
The present and future of solution NMR in investigating the structure and dynamics of channels and transporters.
The present and future of solution NMR in investigating the structure and dynamics of channels and transporters.
Curr Opin Struct Biol. 2013 Apr 26;
Authors: Oxenoid K, Chou JJ
Abstract
Membrane channels, transporters and receptors constitute essential means for cells to maintain homeostasis and communicate with the surroundings. Investigation of their molecular architecture and the dynamic process of transporting substrate or...
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05-01-2013 11:46 AM
NMR Spectroscopy: Past Papers
NMR Spectroscopy: Past Papers
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NMR Spectroscopy: Past Papers
Questions on the topics from several Examining Boards over 5 or more consecutive papers. Try them out before looking at the solutions. Frank Scullion Presentation and Production: Frank Scullion
From:Franklychemistry
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The past, present, and future of 1.26 T2
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