Nitroxide-based radicals are essential to many DNP-NMR experiments and a profound understanding of their chemistry is essential to synthesize new polarizing agents with increased DNP performance. This book gives a comprehensive overview of nitroxides - a good introduction for the new comer but also a reference guide for the expert.
Likhtenshtein, Gertz I. Nitroxides: Brief History, Fundamentals, and Recent Developments. Springer Series in Materials Science. Springer International Publishing, 2020.
Written by a pioneer in the development of spin labeling in biophysics, this expert book covers the fundamentals of nitroxide spin labeling through cutting-edge applications in chemistry, physics, materials science, molecular biology, and biomedicine. Nitroxides have earned their place as one of the most popular organic paramagnets due to their suitability as inhibitors of oxidative processes, as a means to polarize magnetic nuclei, and, in molecular biology, as probes and labels to understand molecular structures and dynamics AS DRAGS FOR CANCER AND OTHER DISEASES. Beginning with an overview of the basic methodology and nitroxides’ 145-year history, this book equips students with necessary background and techniques to undertake original research and industry work in this growing field.
[NMR paper] Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
Related Articles Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
J Mol Med (Berl). 2017 Jun 23;:
Authors: Ziarek JJ, Baptista D, Wagner G
Abstract
Visualizing post-translational modifications, conformations, and interaction surfaces of protein structures at atomic resolution underpins the development of novel therapeutics to combat disease. As computational resources expand, in silico calculations...
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06-24-2017 08:20 PM
Room-temperature electron spin relaxation of nitroxides immobilized in trehalose: Effect of substituents adjacent to NO-group
From The DNP-NMR Blog:
Room-temperature electron spin relaxation of nitroxides immobilized in trehalose: Effect of substituents adjacent to NO-group
Kuzhelev, A.A., et al., Room-temperature electron spin relaxation of nitroxides immobilized in trehalose: Effect of substituents adjacent to NO-group. J. Magn. Reson., 2016. 266: p. 1-7.
http://www.sciencedirect.com/science/article/pii/S1090780716001178
[NMR paper] NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Related Articles NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Prog Biophys Mol Biol. 2014 Aug 28;
Authors: Dias DM, Ciulli A
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information...
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09-02-2014 11:17 PM
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes
Publication date: Available online 28 August 2014
Source:Progress in Biophysics and Molecular Biology</br>
Author(s): David M. Dias , Alessio Ciulli</br>
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information on protein structure, dynamics and interaction at an atomic level in solution. Nowadays, in most...
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08-29-2014 05:36 PM
Recent NMR developments applied to organic-inorganic materials
Recent NMR developments applied to organic-inorganic materials
Publication date: Available online 26 October 2013
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Christian Bonhomme , Christel Gervais , Danielle Laurencin</br>
In this contribution, the latest developments in solid state NMR are presented in the field of organic-inorganic (O/I) materials (or hybrid materials). Such materials involve mineral and organic (including polymeric and biological) components, and can exhibit complex O/I interfaces. Hybrids are currently a major...
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10-26-2013 03:56 AM
[NMR images] History of the SCSB NMR
http://www.nmr.utmb.edu/images/Varian_NMR800.png
http://www.nmr.utmb.edu/scsb_nmr_history.html
15/05/2012 5:08:27 AM GMT
History of the SCSB NMR
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05-31-2012 05:03 PM
Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Recent Developments in (15)N NMR Relaxation Studies that Probe Protein Backbone Dynamics.
Top Curr Chem. 2011 Sep 7;
Authors: Ishima R
Abstract
Nuclear Magnetic Resonance (NMR) relaxation is a powerful technique that provides information about internal dynamics associated with configurational energetics in proteins, as well as site-specific information involved in conformational equilibria. In particular, (15)N relaxation is a useful probe to...
Nitroxides: Brief History, Fundamentals, and Recent Developments #DNPNMR
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