Stevens, T.K., R.M. Ramirez, and A. Pines, Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR. J. Am. Chem. Soc., 2013. 135(26): p. 9576-9579.
<div style="text-align: justify;">A new type of contrast agent for Xe NMR based on surfactant-stabilized perfluorocarbon-in-water nanoemulsions has been produced. The contrast agent uses dissolved hyperpolarized xenon gas as a nonperturbing reporting medium, as xenon freely exchanges between aqueous solution and the perfluorocarbon interior of the droplets, which are spectroscopically distinguishable and allow for chemical exchange saturation transfer (CEST) detection of the agent. Nanoemulsions with droplet diameters between 160 and 310 nm were produced and characterized using hyperpolarized 129Xe combined with CEST detection. Saturation parameters were varied and data were modeled numerically to determine the xenon exchange dynamics of the system. Nanoemulsion droplets were detected at concentrations as low as 100 fM, corresponding to
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Nanoemulsion Contrast Agents with Sub-picomolar Sensitivityfor Xenon NMR
Nanoemulsion Contrast Agents with Sub-picomolar Sensitivityfor Xenon NMR
Todd K. Stevens, R. Matthew Ramirez and Alexander Pines
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja402885q/aop/images/medium/ja-2013-02885q_0003.gif
Journal of the American Chemical Society
DOI: 10.1021/ja402885q
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/tOmAQoYFsGk
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Nanoemulsion Contrast Agents with Sub-picomolar Sensitivity for Xenon NMR
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