Graafen, D., et al., Magnetic resonance imaging of (1)H long lived states derived from parahydrogen induced polarization in a clinical system. J Magn Reson, 2016. 262: p. 68-72.
Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. (13)C-(13)C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus (1)H for e.g. metabolic imaging in the future.
Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging
From The DNP-NMR Blog:
Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging
Kiryutin, A.S., et al., Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging. J Magn Reson, 2015. 261: p. 64-72.
http://www.ncbi.nlm.nih.gov/pubmed/26529204
nmrlearner
News from NMR blogs
0
03-25-2016 04:12 PM
Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
nmrlearner
News from NMR blogs
0
02-13-2015 05:31 PM
Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
nmrlearner
News from NMR blogs
0
02-04-2015 09:57 PM
Long-lived localization in magnetic resonance imaging
From The DNP-NMR Blog:
Long-lived localization in magnetic resonance imaging
Dumez, J.-N., et al., Long-lived localization in magnetic resonance imaging. J. Magn. Reson., 2014. 246(0): p. 27-30.
http://dx.doi.org/10.1016/j.jmr.2014.06.008
nmrlearner
News from NMR blogs
0
10-16-2014 12:12 AM
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
From The DNP-NMR Blog:
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
Buratto, R., et al., Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR. ChemMedChem, 2014: p. n/a-n/a.
http://www.ncbi.nlm.nih.gov/pubmed/25196781
nmrlearner
News from NMR blogs
0
09-27-2014 01:54 AM
Long-lived localization in magnetic resonance imaging
From The DNP-NMR Blog:
Long-lived localization in magnetic resonance imaging
Dumez, J.N., et al., Long-lived localization in magnetic resonance imaging. J Magn Reson, 2014. 246C(0): p. 27-30.
http://www.ncbi.nlm.nih.gov/pubmed/25063953
nmrlearner
News from NMR blogs
0
09-15-2014 07:13 PM
[NMR paper] Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Related Articles Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
ChemMedChem. 2014 Sep 4;
Authors: Buratto R, Bornet A, Milani J, Mammoli D, Vuichoud B, Salvi N, Singh M, Laguerre A, Passemard S, Gerber-Lemaire S, Jannin S, Bodenhausen G
Abstract
Transverse and longitudinal relaxation times (T1? and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived...
nmrlearner
Journal club
0
09-10-2014 11:24 AM
Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization
From The DNP-NMR Blog:
Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization
Meier, B., et al., Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization. J Am Chem Soc, 2013. 135(50): p. 18746-9.
http://www.ncbi.nlm.nih.gov/pubmed/24252212
Magnetic resonance imaging of (1)H long lived states derived from parahydrogen induced polarization in a clinical system #DNPNMR
Linear Mode
