Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution
 

From The DNP-NMR Blog:

Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution

Chen, H.-Y. and R. Tycko, Low-temperature magnetic resonance imaging with 2.8 ?m isotropic resolution. Journal of Magnetic Resonance, 2018. 287: p. 47-55.


http://www.sciencedirect.com/science...90780717303087




We demonstrate the feasibility of high-resolution 1H magnetic resonance imaging (MRI) at low temperatures by obtaining an MRI image of 20 ?m diameter glass beads in glycerol/water at 28 K with 2.8 ?m isotropic resolution. The experiments use a recently-described MRI apparatus (Moore and Tycko, 2015) with minor modifications. The sample is contained within a radio-frequency microcoil with 150 ?m inner diameter. Sensitivity is additionally enhanced by paramagnetic doping, optimization of the sample temperature, three-dimensional phase-encoding of k-space data, pulsed spin-lock detection of 1H nuclear magnetic resonance signals, and spherical sampling of k-space. We verify that the actual image resolution is 2.7 ± 0.3 ?m by quantitative comparisons of experimental and calculated images. Our imaging approach is compatible with dynamic nuclear polarization, providing a path to significantly higher resolution in future experiments.


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