The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4% net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future.
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Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
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02-13-2015 05:31 PM
Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
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02-04-2015 09:57 PM
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
From The DNP-NMR Blog:
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
Buratto, R., et al., Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR. ChemMedChem, 2014. 9(11): p. 2509-2515.
http://dx.doi.org/10.1002/cmdc.201402214
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12-20-2014 02:29 AM
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
From The DNP-NMR Blog:
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
Buratto, R., et al., Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR. ChemMedChem, 2014: p. n/a-n/a.
http://www.ncbi.nlm.nih.gov/pubmed/25196781
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09-27-2014 01:54 AM
[NMR paper] Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Related Articles Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
ChemMedChem. 2014 Sep 4;
Authors: Buratto R, Bornet A, Milani J, Mammoli D, Vuichoud B, Salvi N, Singh M, Laguerre A, Passemard S, Gerber-Lemaire S, Jannin S, Bodenhausen G
Abstract
Transverse and longitudinal relaxation times (T1? and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived...
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09-10-2014 11:24 AM
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Nicola Salvi, Roberto Buratto, Aure?lien Bornet, Simone Ulzega, Inmaculada Rentero Rebollo, Alessandro Angelini, Christian Heinis and Geoffrey Bodenhausen
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja303301w/aop/images/medium/ja-2012-03301w_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja303301w
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/xsuzyMhXJF4
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06-28-2012 07:54 AM
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Chemphyschem. 2011 Aug 31;
Authors: Bornet A, Ahuja P, Sarkar R, Fernandes L, Hadji S, Lee SY, Haririnia A, Fushman D, Bodenhausen G, Vasos PR
Abstract
The relaxation of long-lived states (LLS) corresponds to the slow return to statistical thermal equilibrium between symmetric and antisymmetric proton spin states. This process is remarkably sensitive to the presence of external spins and can be used to obtain...
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09-02-2011 05:40 PM
[NMR paper] A high-resolution NMR study of long-lived water molecules in both oxidation states of
A high-resolution NMR study of long-lived water molecules in both oxidation states of a minimal cytochrome c.
Related Articles A high-resolution NMR study of long-lived water molecules in both oxidation states of a minimal cytochrome c.
Biochemistry. 2003 Apr 1;42(12):3457-63
Authors: Bertini I, Ghosh K, Rosato A, Vasos PR
The interaction of water with oxidized and reduced cytochrome c from the Gram-positive bacterium Bacillus pasteurii (a 71-amino acid long monoheme cytochrome) is investigated through CLEANEX experiments and (15)N-edited...
Long-lived states to sustain SABRE hyperpolarised magnetisation
Linear Mode
