Kiryutin, A.S., et al., Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging. J Magn Reson, 2015. 261: p. 64-72.
A method is proposed to create Long-Lived spin States (LLSs) from longitudinal spin magnetization, which is based on adiabatic switching of a Radio-Frequency (RF) field with proper frequency. The technique is simple to implement with standard Nuclear Magnetic Resonance (NMR) equipment, providing an excellent conversion of population from the triplet T+ (or T-) state to the singlet state of a pair of spins and back. The method has been tested for the amino acid tyrosine and its partially deuterated isotopomer; for the deuterated compound, we have achieved a LLS lifetime, which exceeds the longitudinal relaxation time by a factor of 21. Furthermore, by slightly modifying the method, an enhanced contrast with respect to LLSs in NMR spectra is achieved; contrast enhancements of more than 1200 are feasible. This enables efficient suppression of longitudinal spin magnetization in NMR allowing one to look selectively at LLSs. Using this method we have demonstrated that not only spectral but also spatial contrast can be achieved: we have obtained spatial NMR images with strongly improved contrast originating from the difference of LLS lifetimes at different positions in the sample.
Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
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02-13-2015 05:31 PM
Long-lived spin States for low-field hyperpolarized gas MRI
From The DNP-NMR Blog:
Long-lived spin States for low-field hyperpolarized gas MRI
Kovtunov, K.V., et al., Long-lived spin States for low-field hyperpolarized gas MRI. Chemistry, 2014. 20(45): p. 14629-32.
http://www.ncbi.nlm.nih.gov/pubmed/25263795
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02-04-2015 09:57 PM
Long-lived localization in magnetic resonance imaging
From The DNP-NMR Blog:
Long-lived localization in magnetic resonance imaging
Dumez, J.-N., et al., Long-lived localization in magnetic resonance imaging. J. Magn. Reson., 2014. 246(0): p. 27-30.
http://dx.doi.org/10.1016/j.jmr.2014.06.008
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10-16-2014 12:12 AM
Long-lived localization in magnetic resonance imaging
From The DNP-NMR Blog:
Long-lived localization in magnetic resonance imaging
Dumez, J.N., et al., Long-lived localization in magnetic resonance imaging. J Magn Reson, 2014. 246C(0): p. 27-30.
http://www.ncbi.nlm.nih.gov/pubmed/25063953
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09-15-2014 07:13 PM
[NMR paper] Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Related Articles Exploring Weak Ligand-Protein Interactions by Long-Lived NMR States : Improved Contrast in Fragment-Based Drug Screening.
Angew Chem Int Ed Engl. 2014 Sep 4;
Authors: Buratto R, Mammoli D, Chiarparin E, Williams G, Bodenhausen G
Abstract
Ligands that have an affinity for protein targets can be screened very effectively by exploiting favorable properties of long-lived states (LLS) in NMR...
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09-10-2014 11:24 AM
Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization
From The DNP-NMR Blog:
Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization
Meier, B., et al., Long-lived nuclear spin states in methyl groups and quantum-rotor-induced polarization. J Am Chem Soc, 2013. 135(50): p. 18746-9.
http://www.ncbi.nlm.nih.gov/pubmed/24252212
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02-13-2014 01:42 AM
Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization
From The DNP-NMR Blog:
Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization
Chen, L., et al., Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization. Magnetics, IEEE Transactions on, 2013. 49(7): p. 3528-3532.
http://dx.doi.org/10.1109/TMAG.2013.2239268
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08-23-2013 02:29 PM
[NMR paper] Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan 17;
Authors: Xue S, Qiao J, Pu F, Cameron M, Yang JJ
Abstract
Magnetic...
Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging
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