The longitudinal nuclear relaxation time, T1, sets a stringent limit on the range of information that can be obtained from magnetic resonance imaging (MRI) experiments. Long-lived nuclear spin states provide a possibility to extend the timescale over which information can be encoded in magnetic resonance. We introduce a strategy to localize an ensemble of molecules for a significantly extended duration ( approximately 30 times longer than T1 in this example), using a spatially selective conversion between magnetization and long-lived singlet order. An application to tagging and transport is proposed.
[NMR paper] Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
Related Articles Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR.
ChemMedChem. 2014 Sep 4;
Authors: Buratto R, Bornet A, Milani J, Mammoli D, Vuichoud B, Salvi N, Singh M, Laguerre A, Passemard S, Gerber-Lemaire S, Jannin S, Bodenhausen G
Abstract
Transverse and longitudinal relaxation times (T1? and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived...
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09-10-2014 11:24 AM
Storage of nuclear magnetization as long-lived singlet order in low magnetic field
From The DNP-NMR Blog:
Storage of nuclear magnetization as long-lived singlet order in low magnetic field
This week I will catch up with some articles that were published in the Proceedings of the National Academy of Sciences that slipped through the crack.
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07-21-2014 05:32 PM
Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization
From The DNP-NMR Blog:
Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization
Chen, L., et al., Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization. Magnetics, IEEE Transactions on, 2013. 49(7): p. 3528-3532.
http://dx.doi.org/10.1109/TMAG.2013.2239268
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08-23-2013 02:29 PM
Design of a 13C magnetic resonance probe using a deuterated methoxy group as a long-lived hyperpolarization unit
From the The DNP-NMR Blog:
Design of a 13C magnetic resonance probe using a deuterated methoxy group as a long-lived hyperpolarization unit
Doura, T., et al., Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit. Angew. Chem. Int. Ed., 2012. 51(40): p. 10114-10117.
http://www.ncbi.nlm.nih.gov/pubmed/22961955
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04-15-2013 08:52 AM
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Nicola Salvi, Roberto Buratto, Aure?lien Bornet, Simone Ulzega, Inmaculada Rentero Rebollo, Alessandro Angelini, Christian Heinis and Geoffrey Bodenhausen
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja303301w/aop/images/medium/ja-2012-03301w_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja303301w
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/xsuzyMhXJF4
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06-28-2012 07:54 AM
Long-lived coherences for line-narrowing in high-field NMR
Long-lived coherences for line-narrowing in high-field NMR
Publication year: 2011
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 59, Issue 1</br>
Riddhiman Sarkar, Puneet Ahuja, Paul R. Vasos, Aurélien Bornet, Olivier Wagnières, Geoffrey Bodenhausen</br>
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03-09-2012 09:16 AM
Long-Lived Coherences for Line-Narrowing in High-Field NMR
Long-Lived Coherences for Line-Narrowing in High-Field NMR
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 21 October 2010</br>
Riddhiman, Sarkar , Puneet, Ahuja , Paul R., Vasos , Aurélien, Bornet , Olivier, Wagnières , ...</br>
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10-22-2010 07:34 AM
Long-Lived Coherences for Homogeneous Line Narrowing in Spec
Long-Lived Coherences for Homogeneous Line Narrowing in Spec
Physical Review Letters publication on application of long-lived coherences to line-narrowing in NMR by Dr. Geoffrey Bodenhausen and his group.
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