Hyperpolarization via dissolution Dynamic Nuclear Polarization (dDNP) is crucial to significantly increase the magnetic resonance imaging (MRI) sensitivity, opening up for in vivo real-time MRI using in particular 13C-labelled substrates. The range of applications is however limited by the relatively fast decay of the nuclear spin polarization together with the constraint of having to polarize the spins near the MRI magnet. As recently demonstrated, the employment of UV-induced non-persistent radicals represents an elegant solution to tackle these drawbacks. Nevertheless, since its introduction, the spread of the technique has been prevented by the relatively low achievable polarization, slow buildup time and time-consuming sample preparation. In the present work, thanks to a thorough investigation of the radical generation step, we provide a robust protocol to enhance the efficiency and performance of the UV-radical technique. Under optimal conditions, it was possible to produce up to 60 mM radical in less than 5 min, and reach maximum DNP enhancement with a buildup time constant of approx. 25 min, at 6.7 T and 1 K, resulting in 30% 13C liquid-state polarization.
Photo-induced radical polarization and liquid-state dynamic nuclear polarization using fullerene nitroxide derivatives #DNPNMR
From The DNP-NMR Blog:
Photo-induced radical polarization and liquid-state dynamic nuclear polarization using fullerene nitroxide derivatives #DNPNMR
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Liu, G., et al., Photo-induced radical polarization and liquid-state dynamic nuclear polarization using fullerene nitroxide derivatives. Phys. Chem. Chem. Phys., 2017. 19(47): p. 31823-31829.
https://www.ncbi.nlm.nih.gov/pubmed/29171613
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02-14-2018 04:47 PM
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR #NMR
From The DNP-NMR Blog:
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR #NMR
Most commonly nitroxide-based radicals are used in DNP. However, there are many other stable radicals. This one is a UV generated radical that is stable for weeks at room temperature. In addition it exhibits a fairly narrow linewidth. This radical, in combination with another narrow line radical (BDPA, trityl, etc.) could make a very efficient polarizing agent when mixed together or even...
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02-12-2018 05:58 PM
Pulsed Dynamic Nuclear Polarization with Trityl Radicals #DNPNMR
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Pulsed Dynamic Nuclear Polarization with Trityl Radicals #DNPNMR
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Mathies, G., et al., Pulsed Dynamic Nuclear Polarization with Trityl Radicals. The Journal of Physical Chemistry Letters, 2016. 7(1): p. 111-116.
https://www.ncbi.nlm.nih.gov/pubmed/26651876
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02-02-2018 06:44 AM
Photo-induced radical polarization and liquid-state dynamic nuclear polarization with fullerene nitroxide derivatives
From The DNP-NMR Blog:
Photo-induced radical polarization and liquid-state dynamic nuclear polarization with fullerene nitroxide derivatives
DNP without microwave radiation? A very interesting approach.
Liu, G., et al., Photo-induced radical polarization and liquid-state dynamic nuclear polarization with fullerene nitroxide derivatives. Phys. Chem. Chem. Phys., 2017.
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12-04-2017 03:35 PM
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR
From The DNP-NMR Blog:
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR
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DeHaven, B.A., et al., Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy. Chemistry, 2017. 23(34): p. 8315-8319.
https://www.ncbi.nlm.nih.gov/pubmed/28423212
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10-05-2017 01:01 AM
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates
From The DNP-NMR Blog:
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates
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Capozzi, A., et al., Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13C-substrates. 2017. 8: p. 15757.
http://dx.doi.org/10.1038/ncomms15757
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07-28-2017 10:21 PM
Dynamic nuclear polarization in solid samples by electrical-discharge-induced radicals
From The DNP-NMR Blog:
Dynamic nuclear polarization in solid samples by electrical-discharge-induced radicals
Katz, I. and A. Blank, Dynamic nuclear polarization in solid samples by electrical-discharge-induced radicals. J Magn Reson, 2015. 261: p. 95-100.
http://www.ncbi.nlm.nih.gov/pubmed/26547016
Liquid-State 13C Polarization of 30% through Photo-Induced Non-Persistent Radicals #DNPNMR
Linear Mode
