LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

		BioNMR > NMR community > News from NMR blogs
LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

11-08-2014, 12:08 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,714

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

From The DNP-NMR Blog:

LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization

Theis, T., et al., LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization. J Magn Reson, 2014. 248C(0): p. 23-26.

http://www.ncbi.nlm.nih.gov/pubmed/25299767

Nuclear spin hyperpolarization overcomes the sensitivity limitations of traditional NMR and MRI, but the most general method demonstrated to date (dynamic nuclear polarization) has significant limitations in scalability, cost, and complex apparatus design. As an alternative, signal amplification by reversible exchange (SABRE) of parahydrogen on transition metal catalysts can hyperpolarize a variety of substrates, but to date this scheme has required transfer of the sample to low magnetic field or very strong RF irradiation. Here we demonstrate "Low-Irradiation Generation of High Tesla-SABRE" (LIGHT-SABRE) which works with simple pulse sequences and low power deposition; it should be usable at any magnetic field and for hyperpolarization of many different nuclei. This approach could drastically reduce the cost and complexity of producing hyperpolarized molecules.

Go to The DNP-NMR Blog for more info.

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Achieving 1% NMR polarization in water in less than 1min using SABRE From The DNP-NMR Blog: Achieving 1% NMR polarization in water in less than 1min using SABRE Zeng, H., et al., Achieving 1% NMR polarization in water in less than 1min using SABRE. J Magn Reson, 2014. 246C(0): p. 119-121. http://www.ncbi.nlm.nih.gov/pubmed/25123540	nmrlearner	News from NMR blogs	0	09-12-2014 06:37 PM
Toward nanomolar detection by NMR through SABRE hyperpolarization From The DNP-NMR Blog: Toward nanomolar detection by NMR through SABRE hyperpolarization Eshuis, N., et al., Toward nanomolar detection by NMR through SABRE hyperpolarization. J Am Chem Soc, 2014. 136(7): p. 2695-8. http://www.ncbi.nlm.nih.gov/pubmed/24475903	nmrlearner	News from NMR blogs	0	05-09-2014 07:01 PM
Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments From The DNP-NMR Blog: Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments Pravdivtsev, A.N., et al., Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments. ChemPhysChem, 2013. 14(14): p. 3327-3331. http://www.ncbi.nlm.nih.gov/pubmed/23959909	nmrlearner	News from NMR blogs	0	04-16-2014 11:09 PM
The Feasibilityof Formation and Kinetics of NMR SignalAmplification by Reversible Exchange (SABRE) at High Magnetic Field(9.4 T) The Feasibilityof Formation and Kinetics of NMR SignalAmplification by Reversible Exchange (SABRE) at High Magnetic Field(9.4 T) Danila A. Barskiy, Kirill V. Kovtunov, Igor V. Koptyug, Ping He, Kirsten A. Groome, Quinn A. Best, Fan Shi, Boyd M. Goodson, Roman V. Shchepin, Aaron M. Coffey, Kevin W. Waddell and Eduard Y. Chekmenev http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja501052p/aop/images/medium/ja-2014-01052p_0005.gif Journal of the American Chemical Society DOI: 10.1021/ja501052p...	nmrlearner	Journal club	0	02-25-2014 12:44 AM
TowardNanomolar Detection by NMR Through SABRE Hyperpolarization TowardNanomolar Detection by NMR Through SABRE Hyperpolarization Nan Eshuis, Niels Hermkens, Bram J. A. van Weerdenburg, Martin C. Feiters, Floris P. J. T. Rutjes, Sybren S. Wijmenga and Marco Tessari http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja412994k/aop/images/medium/ja-2013-12994k_0006.gif Journal of the American Chemical Society DOI: 10.1021/ja412994k http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/jacsat/~4/CRRo27dOPlc	nmrlearner	Journal club	0	02-05-2014 06:08 PM
Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid From The DNP-NMR Blog: Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid Zeng, H., et al., Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid. J Magn Reson, 2013. 237(0): p. 73-8. http://www.ncbi.nlm.nih.gov/pubmed/24140625	nmrlearner	News from NMR blogs	0	12-18-2013 04:00 PM
A Novel Tri-Enzyme System in Combination with Laser-Driven NMR Enables Efficient Nuclear Polarization of Biomolecules in Solution From The DNP-NMR Blog: A Novel Tri-Enzyme System in Combination with Laser-Driven NMR Enables Efficient Nuclear Polarization of Biomolecules in Solution Lee, J.H. and S. Cavagnero, A Novel Tri-Enzyme System in Combination with Laser-Driven NMR Enables Efficient Nuclear Polarization of Biomolecules in Solution. The Journal of Physical Chemistry B, 2013. 117(20): p. 6069-6081. http://dx.doi.org/10.1021/jp4010168	nmrlearner	News from NMR blogs	0	07-10-2013 05:30 PM
Utilization of SABRE-DerivedHyperpolarization ToDetect Low-Concentration Analytes via 1D and 2D NMR Methods Utilization of SABRE-DerivedHyperpolarization ToDetect Low-Concentration Analytes via 1D and 2D NMR Methods Lyrelle S. Lloyd, Ralph W. Adams, Michael Bernstein, Steven Coombes, Simon B. Duckett, Gary G. R. Green, Richard. J. Lewis, Ryan E. Mewis and Christopher J. Sleigh http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja3051052/aop/images/medium/ja-2012-051052_0006.gif Journal of the American Chemical Society DOI: 10.1021/ja3051052 http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA...	nmrlearner	Journal club	0	07-27-2012 11:58 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is Off Trackbacks are Off Pingbacks are Off Refbacks are Off