We introduce hyperpolarizable 13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable 13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
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Hyperpolarized choline as an MR imaging molecular probe: feasibility of in vivo imaging in a rat model
From The DNP-NMR Blog:
Hyperpolarized choline as an MR imaging molecular probe: feasibility of in vivo imaging in a rat model
Friesen-Waldner, L.J., et al., Hyperpolarized choline as an MR imaging molecular probe: feasibility of in vivo imaging in a rat model. J Magn Reson Imaging, 2015. 41(4): p. 917-23.
http://www.ncbi.nlm.nih.gov/pubmed/24862837
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10-22-2015 03:29 AM
Hyperpolarized Xenon-Based Molecular Sensors for Label-Free Detection of analytes
From The DNP-NMR Blog:
Hyperpolarized Xenon-Based Molecular Sensors for Label-Free Detection of analytes
Garimella, P.D., et al., Hyperpolarized Xenon-Based Molecular Sensors for Label-Free Detection of analytes. J. Am. Chem. Soc., 2013. 136(1): p. 164-168.
http://pubs.acs.org/doi/abs/10.1021/ja406760r
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02-28-2014 07:08 PM
In vivo magnetic resonance imaging of hyperpolarized silicon particles
From The DNP-NMR Blog:
In vivo magnetic resonance imaging of hyperpolarized silicon particles
Cassidy, M.C., et al., In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nano, 2013. 8(5): p. 363-368.
http://dx.doi.org/10.1038/nnano.2013.65
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08-29-2013 01:27 AM
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
From the The DNP-NMR Blog:
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
Park, J.M., et al., Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging. Neuro-Oncology, 2013. 15(4): p. 433-41.
http://neuro-oncology.oxfordjournals.org/content/early/2013/01/16/neuonc.nos319.abstract
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04-15-2013 08:52 AM
[NMR paper] Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan 17;
Authors: Xue S, Qiao J, Pu F, Cameron M, Yang JJ
Abstract
Magnetic...
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02-03-2013 10:19 AM
[NMR paper] Altered transition metal homeostasis in mice following manganese injections for manganese-enhanced magnetic resonance imaging.
Altered transition metal homeostasis in mice following manganese injections for manganese-enhanced magnetic resonance imaging.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Altered transition metal homeostasis in mice following manganese injections for manganese-enhanced magnetic resonance imaging.
Biometals. 2013 Feb;26(1):179-87
Authors: Moldovan N, Al-Ebraheem A, Miksys NA, Farquharson MJ, Bock NA
Abstract
In manganese-enhanced magnetic resonance...
Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging
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