Hyperpolarized H2O MR angiography

		BioNMR > NMR community > News from NMR blogs
Hyperpolarized H2O MR angiography

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

03-28-2014, 04:59 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,777

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Hyperpolarized H2O MR angiography

From The DNP-NMR Blog:

Hyperpolarized H2O MR angiography

Ardenkjaer-Larsen, J.H., et al., Hyperpolarized H2 O MR angiography. Magn Reson Med, 2014. 71(1): p. 50-6.

http://www.ncbi.nlm.nih.gov/pubmed/24243653

PURPOSE: The aim of this study was to demonstrate that dissolution- dynamic nuclear polarization is capable of hyperpolarizing water protons and that the signal from the hyperpolarized bolus injection can be exploited in angiographic applications. METHODS: We hyperpolarized water/glycerol using dynamic nuclear polarization followed by dissolution in D2 O. RESULTS: A water (1) H signal enhancement of 77 times compared with 4.7 Tesla was obtained. This corresponds to a polarization of 3.5% for the 3.9 mol/L (1) H in D2 O . Moreover, a T1 in excess of 20 s was achieved. CONCLUSION: The use of hyperpolarized water as a contrast agent presents a new opportunity to obtain MRA images with high contrast-to-noise in a fraction of a second.

Go to The DNP-NMR Blog for more info.

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Postdoc position (in vivo hyperpolarized 13C MR) From The DNP-NMR Blog: Postdoc position (in vivo hyperpolarized 13C MR) The University of Maryland School of Medicine is expanding its molecular imaging and interventional research capabilities with the addition of a Dynamic Nuclear Polarizer and High-Intensity Focused Ultrasound as part of the recently established Center for Integration of Metabolic Imaging and Therapeutics (CIMIT). This expansion is aimed to facilitate both basic science and clinical research by exploring novel molecular imaging agent based technologies for screening, early detection, and real-time...	nmrlearner	News from NMR blogs	0	11-21-2013 01:14 AM
Cardiovascular Applications of Hyperpolarized MRI From The DNP-NMR Blog: Cardiovascular Applications of Hyperpolarized MRI Tyler, D., Cardiovascular Applications of Hyperpolarized MRI. Curr Cardiovasc Imaging Rep, 2011. 4(2): p. 108-115. http://dx.doi.org/10.1007/s12410-011-9066-8 Many applications of MRI are limited by an inherently low sensitivity. Previous attempts to overcome this insensitivity have focused on the use of MRI systems with stronger magnetic fields. However, the gains that can be achieved in this way are relatively small and increasing the magnetic field invariably leads to greater technical...	nmrlearner	News from NMR blogs	0	07-15-2013 07:17 PM
MR Physicist/Engineer Position for Hyperpolarized DNP NMR/MRI From The DNP-NMR Blog: MR Physicist/Engineer Position for Hyperpolarized DNP NMR/MRI This was originally posted on the ISMRM webpage at: http://www.ismrm.org/jobs/J04941.pdf MR Physicist/Engineer Position for Hyperpolarized DNP NMR/MRI	nmrlearner	News from NMR blogs	0	04-17-2013 08:13 AM
Perspectives of hyperpolarized noble gas MRI beyond 3He From the The DNP-NMR Blog: Perspectives of hyperpolarized noble gas MRI beyond 3He Lilburn, D.M.L., G.E. Pavlovskaya, and T. Meersmann, Perspectives of hyperpolarized noble gas MRI beyond 3He. J. Magn. Reson., 2013. 229(0): p. 173-186. http://www.sciencedirect.com/science/article/pii/S1090780712003588	nmrlearner	News from NMR blogs	0	04-15-2013 08:52 AM
Hyperpolarized (13) C-labelled anhydrides as DNP precursors of metabolic MRI agents From the The DNP-NMR Blog: Hyperpolarized (13) C-labelled anhydrides as DNP precursors of metabolic MRI agents Colombo Serra, S., et al., Hyperpolarized 13C-labelled anhydrides as DNP precursors of metabolic MRI agents. Contrast Media & Molecular Imaging, 2012. 7(5): p. 469-477. http://www.ncbi.nlm.nih.gov/pubmed/22821881	nmrlearner	News from NMR blogs	0	04-15-2013 08:52 AM
The DNP-NMR Blog: Postdoctoral position in hyperpolarized singlet ... The DNP-NMR Blog: Postdoctoral position in hyperpolarized singlet ... Too busy to scan scientific journals for articles about Dynamic Nuclear Polarization enhanced NMR spectroscopy (DNP-NMR) and related Terahertz ( THz) ... blog.bridge12.com/.../postdoctoral-position-in-hyperpolarized... More...	nmrlearner	Job marketplace	0	03-30-2012 10:45 AM
[NMR paper] Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR. Related Articles Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR. J Am Chem Soc. 1999 Oct 13;121(40):9370-7 Authors: Bowers CR, Storhaug V, Webster CE, Bharatam J, Cottone A, Gianna R, Betsey K, Gaffney BJ This paper presents an exploratory study of the binding interactions of xenon with the surface of several different proteins in the solution and solid states using both conventional and...	nmrlearner	Journal club	0	11-18-2010 08:31 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is Off Trackbacks are Off Pingbacks are Off Refbacks are Off