Dynamic nuclear polarization (DNP) enhances the sensitivity of solid-state NMR (SSNMR) spectroscopy by orders of magnitude and, therefore, opens possibilities for novel applications from biology to materials science. This multitude of opportunities implicates a need for high-performance polarizing agents, which integrate specific physical and chemical features tailored for various applications. Here, we demonstrate that for the biradical bTbK in complex with captisol (CAP), a beta-cyclodextrin derivative, host-guest assembling offers a new and easily accessible approach for the development of new polarizing agents. In contrast to bTbK, the CAP-bTbK complex is water-soluble and shows significantly improved DNP performance compared to the commonly used DNP agent TOTAPOL. Furthermore, NMR and EPR data reveal improved electron and nuclear spin relaxation properties for bTbK within the host molecule. The numerous possibilities to functionalize host molecules will permit designing novel radical complexes targeting diverse applications.
Highly Efficient, Water-Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency
From The DNP-NMR Blog:
Highly Efficient, Water-Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency
Sauvee, C., et al., Highly Efficient, Water-Soluble Polarizing Agents for Dynamic Nuclear Polarization at High Frequency. Angew Chem Int Ed Engl, 2013. 52(41): p. 10858-10861.
http://www.ncbi.nlm.nih.gov/pubmed/23956072
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11-22-2013 03:09 PM
[NMR paper] NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond.
NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond.
Angew Chem Int Ed Engl. 2013 Jul 19;
Authors: Mainz A, Religa TL, Sprangers R, Linser R, Kay LE, Reif B
Abstract
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07-23-2013 09:52 PM
Can metal ion complexes be used as polarizing agents for solution DNP? A theoretical discussion
From The DNP-NMR Blog:
Can metal ion complexes be used as polarizing agents for solution DNP? A theoretical discussion
Luchinat, C., G. Parigi, and E. Ravera, Can metal ion complexes be used as polarizing agents for solution DNP? A theoretical discussion. J. Biomol. NMR, 2013: p. 1-11.
http://www.ncbi.nlm.nih.gov/pubmed/23606273
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06-03-2013 04:21 PM
Chemistry and Structureof a Host–Guest Relationship:The Power of NMR and X-ray Diffraction in Tandem
Chemistry and Structureof a Host–Guest Relationship:The Power of NMR and X-ray Diffraction in Tandem
Qi-Qiang Wang, Victor W. Day and Kristin Bowman-James
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja3096762/aop/images/medium/ja-2012-096762_0013.gif
Journal of the American Chemical Society
DOI: 10.1021/ja3096762
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/Ze2zN3_VFiU
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12-20-2012 04:48 PM
1H NMR Chemical Shift Calculations as a Probe of Supramolecular Host–Guest Geometry
1H NMR Chemical Shift Calculations as a Probe of Supramolecular Host–Guest Geometry
Jeffrey S. Mugridge, Robert G. Bergman and Kenneth N. Raymond
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja202254x/aop/images/medium/ja-2011-02254x_0010.gif
Journal of the American Chemical Society
DOI: 10.1021/ja202254x
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/wR-1b5WtJhc
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06-30-2011 05:01 AM
Nmr structure and action on nicotinic acetylcholine receptors of water-soluble domain of human lynx1.
NMR STRUCTURE AND ACTION ON NICOTINIC ACETYLCHOLINE RECEPTORS OF WATER-SOLUBLE DOMAIN OF HUMAN LYNX1.
NMR STRUCTURE AND ACTION ON NICOTINIC ACETYLCHOLINE RECEPTORS OF WATER-SOLUBLE DOMAIN OF HUMAN LYNX1.
J Biol Chem. 2011 Jan 20;
Authors: Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP
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01-22-2011 01:52 PM
[NMR paper] Interaction of the water-soluble protein aprotinin with liposomes: gel-filtration, tu
Interaction of the water-soluble protein aprotinin with liposomes: gel-filtration, turbidity studies, and 31P NMR studies.
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Authors: Tiourina O, Sharf T, Balkina A, Ollivon M, Selischeva A, Sorokoumova G, Larionova N
The interactions of a water-soluble nonmembrane protein aprotinin with multilamellar vesicles (MLV) and small unilamellar vesicles (SUV) from soybean...
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11-24-2010 09:16 PM
Bruker Introduces Icon, a High-Performance Desktop MRI Syste
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Host-Guest Complexes as Water-Soluble High-Performance DNP Polarizing Agents
Linear Mode
