In yesterday's post I pointed you to an article that has become the most accessed article of all time in the Journal of Cheminformatics, co-authored by representatives of ACD/Labs. This article is a very comprehensive outline of the different approaches,...
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[NMR paper] Solution structure and dynamics of integral membrane proteins by NMR: a case study in
Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP.
Related Articles Solution structure and dynamics of integral membrane proteins by NMR: a case study involving the enzyme PagP.
Methods Enzymol. 2005;394:335-50
Authors: Hwang PM, Kay LE
Solution NMR spectroscopy is rapidly becoming an important technique for the study of membrane protein structure and dynamics. NMR experiments on large perdeuterated proteins typically exploit the favorable relaxation properties of backbone amide...
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11-24-2010 11:14 PM
[NMR paper] Investigating the conformational coupling between the transmembrane and cytoplasmic d
Investigating the conformational coupling between the transmembrane and cytoplasmic domains of a single-spanning membrane protein. A 1H-NMR study.
Related Articles Investigating the conformational coupling between the transmembrane and cytoplasmic domains of a single-spanning membrane protein. A 1H-NMR study.
FEBS Lett. 2001 Sep 21;505(3):431-5
Authors: Mousson F, Beswick V, Coïc YM, Huynh-Dinh T, Sanson A, Neumann JM
PMP1 is a 38-residue single-spanning membrane protein whose C-terminal cytoplasmic domain, Y25-F38, is highly positively...
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11-19-2010 08:44 PM
[NMR paper] Investigating the structure and properties of hydrated hydroxypropyl methylcellulose
Investigating the structure and properties of hydrated hydroxypropyl methylcellulose and egg albumin matrices containing carbamazepine: EPR and NMR study.
Related Articles Investigating the structure and properties of hydrated hydroxypropyl methylcellulose and egg albumin matrices containing carbamazepine: EPR and NMR study.
Pharm Res. 2000 Oct;17(10):1299-308
Authors: Katzhendler I, Mäder K, Azoury R, Friedman M
PURPOSE: The present study was conducted in order to investigate the correlation between the hydration properties of HPMC and EA...
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11-19-2010 08:29 PM
[NMR paper] CD and NMR investigations on trifluoroethanol-induced step-wise folding of helical se
CD and NMR investigations on trifluoroethanol-induced step-wise folding of helical segment from scorpion neurotoxin.
Related Articles CD and NMR investigations on trifluoroethanol-induced step-wise folding of helical segment from scorpion neurotoxin.
Eur J Biochem. 1999 Sep;264(2):468-78
Authors: Khandelwal P, Seth S, Hosur RV
A 14 amino acid residue peptide from the helical region of Scorpion neurotoxin has been structurally characterized using CD and NMR spectroscopy in different solvent conditions. 2,2,2-Trifluoroethanol (TFE) titration has...
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11-18-2010 08:31 PM
NMR Reveals Two-Step Association of Congo Red to Amyloid ? in Low-Molecular-Weight Ag
NMR Reveals Two-Step Association of Congo Red to Amyloid ? in Low-Molecular-Weight Aggregates.
Related Articles NMR Reveals Two-Step Association of Congo Red to Amyloid ? in Low-Molecular-Weight Aggregates.
J Phys Chem B. 2010 Nov 15;
Authors: Pedersen MO, Mikkelsen K, Behrens MA, Pedersen JS, Enghild JJ, Skrydstrup T, Malmendal A, Nielsen NC
Aggregation of the Amyloid ? peptide into amyloid fibrils is closely related to development of Alzheimer's disease. Many small aromatic compounds have been found to act as inhibitors of fibril formation, and...
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11-17-2010 05:49 PM
[NMR paper] A case history. NMR studies of the structure of a small protein, omega-conotoxin MVII
A case history. NMR studies of the structure of a small protein, omega-conotoxin MVIIA.
Related Articles A case history. NMR studies of the structure of a small protein, omega-conotoxin MVIIA.
Methods Mol Biol. 1997;60:337-62
Authors: MacLachlan LK, Middleton DA, Edwards AJ, Reid DG
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08-22-2010 03:31 PM
[NMR paper] A case history. NMR studies of the structure of a small protein, omega-conotoxin MVII
A case history. NMR studies of the structure of a small protein, omega-conotoxin MVIIA.
Related Articles A case history. NMR studies of the structure of a small protein, omega-conotoxin MVIIA.
Methods Mol Biol. 1997;60:337-62
Authors: MacLachlan LK, Middleton DA, Edwards AJ, Reid DG
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08-22-2010 03:03 PM
[Ryan's blog] A Case for more NMR, and maybe even Automated Structure Verification?
Source: Ryan's blog
A Case for more NMR, and maybe even Automated Structure Verification?
I've spent a lot of time over the past couple of years visiting both scientists and directors in Pharma and having discussions around the concept of automated structure verification, whether or not there is enough characterization being done on screens,...
From FID to Structure in 30 Minutes? Investigating the CASE Limiting Step
Linear Mode
