Dissolution DNP has become an important method to generate highly polarized substrates such as pyruvic acid for in vivo imaging and localized spectroscopy. In a quest to further increase the polarization levels, which is important for in vivo MRI employing 13C detection, we describe the design and implementation of a new DNP polarizer that is suitable for dissolution operation at 7 T static magnetic field and a temperature of 1.4 K. We describe all important sample preparation steps and experimental details necessary to optimize trityl based samples for use in our polarizer at this higher field. In [1-13C]-pyruvic acid polarization levels of about 56% are achieved, compared to typical polarization levels of about 35-45% at a standard field of 3.4 T. At the same time, the polarization build-up time increases significantly from about 670 s at 3.4 T to around 1300-1900 s at 7 T, depending on the trityl derivate used. We also investigate the effect of adding trace amounts of Gd3+ to the samples. While one trityl compound does not exhibit any benefit, the other profits significantly, boosting achievable polarization by 6%.
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica} p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica}
Construction and 13 C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system #DNPNMR
From The DNP-NMR Blog:
Construction and 13 C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Kiswandhi, A., et al., Construction and 13 C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system. Magn Reson Chem, 2017. 55(9): p. 828-836.
https://www.ncbi.nlm.nih.gov/pubmed/28407455
nmrlearner
News from NMR blogs
0
10-14-2017 02:04 AM
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR
From The DNP-NMR Blog:
Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
DeHaven, B.A., et al., Persistent Radicals of Self-assembled Benzophenone bis-Urea Macrocycles: Characterization and Application as a Polarizing Agent for Solid-state DNP MAS Spectroscopy. Chemistry, 2017. 23(34): p. 8315-8319.
https://www.ncbi.nlm.nih.gov/pubmed/28423212
nmrlearner
News from NMR blogs
0
10-05-2017 01:01 AM
Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls #DNPNMR
From The DNP-NMR Blog:
Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Silverio, D.L., et al., Tailored Polarizing Hybrid Solids with Nitroxide Radicals Localized in Mesostructured Silica Walls. Helvetica Chimica Acta, 2017: p. n/a-n/a.
http://dx.doi.org/10.1002/hlca.201700101
nmrlearner
News from NMR blogs
0
05-05-2017 09:46 PM
Impact of Ho3+-doping on 13C dynamic nuclear polarization using trityl OX063 free radical #DNPNMR
From The DNP-NMR Blog:
Impact of Ho3+-doping on 13C dynamic nuclear polarization using trityl OX063 free radical #DNPNMR
Kiswandhi, A., et al., Impact of Ho3+-doping on 13C dynamic nuclear polarization using trityl OX063 free radical. Phys. Chem. Chem. Phys., 2016. 18(31): p. 21351-21359.
http://dx.doi.org/10.1039/C6CP03954E
nmrlearner
News from NMR blogs
0
09-22-2016 10:41 PM
Conceptual and instrumental progress in dissolution DNP #DNPNMR
From The DNP-NMR Blog:
Conceptual and instrumental progress in dissolution DNP #DNPNMR
Jahnig, F., G. Kwiatkowski, and M. Ernst, Conceptual and instrumental progress in dissolution DNP. J Magn Reson, 2016. 264: p. 22-9.
http://www.ncbi.nlm.nih.gov/pubmed/26920827
Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin
From The DNP-NMR Blog:
Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin
Walker, S.A., et al., Temperature dependence of high field 13C dynamic nuclear polarization processes with trityl radicals below 35 Kelvin. Phys. Chem. Chem. Phys., 2013.
http://dx.doi.org/10.1039/C3CP51628H
nmrlearner
News from NMR blogs
0
09-06-2013 06:52 PM
The interplay between the solid effect and the cross effect mechanisms in solid state 13C DNP at 95 GHz using trityl radicals
From The DNP-NMR Blog:
The interplay between the solid effect and the cross effect mechanisms in solid state 13C DNP at 95 GHz using trityl radicals
Banerjee, D., et al., The interplay between the solid effect and the cross effect mechanisms in solid state 13C DNP at 95 GHz using trityl radicals. J. Magn. Reson., 2013. 230(0): p. 212-219.
http://dx.doi.org/10.1016/j.jmr.2013.02.010
Dissolution DNP using trityl radicals at 7 T field #DNPNMR
Linear Mode
