Dynamic nuclear polarisation has enabled real-time metabolic imaging of pyruvate and its metabolites. Conventional imaging sequences rely on predefined settings and do not account for intersubject variations in biological parameters such as perfusion. We present a fully automatic real-time bolus tracking sequence for hyperpolarised substrates which starts the imaging acquisition at a defined point on the bolus curve. This reduces artefacts due to signal change and allows for a more efficient use of hyperpolarised magnetisation. For single time point imaging methods, bolus tracking enables a more reliable and consistent quantification of metabolic activity. An RF excitation with a small flip angle is used to obtain slice-selective pyruvate tracking information in rats. Moreover, in combination with a copolarised urea and pyruvate injection, spectrally selective tracking on urea allows obtaining localised bolus tracking information without depleting the pyruvate signal. Particularly with regard to clinical application, the bolus tracking technique could provide an important step towards a routine assessment protocol which removes operator dependencies and ensures comparable results.
Probing the mobility of ibuprofen confined in MCM-41 materials using MAS-PFG NMR and hyperpolarised-(129)Xe NMR spectroscopy
From The DNP-NMR Blog:
Probing the mobility of ibuprofen confined in MCM-41 materials using MAS-PFG NMR and hyperpolarised-(129)Xe NMR spectroscopy
Guenneau, F., et al., Probing the mobility of ibuprofen confined in MCM-41 materials using MAS-PFG NMR and hyperpolarised-(129)Xe NMR spectroscopy. Phys Chem Chem Phys, 2013. 15(43): p. 18805-8.
http://www.ncbi.nlm.nih.gov/pubmed/24100415
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News from NMR blogs
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12-09-2013 03:29 PM
New NMR cancer model: Tracking progress
New NMR cancer model: Tracking progress
http://www.spectroscopynow.com/common/images/thumbnails/141a639aeec.jpgA new modelling technique for real-time tracking of metabolic reactions in tumours has been developed by UK researchers. The system based on a simplified computer model of nuclear magnetic resonance spectra could allow oncologists to assess how well their prescribed treatment, whether chemotherapy, radiotherapy or an immunological treatment is progressing without surgical intervention nor the need for regular biopsies.
Read the rest at Spectroscopynow.com
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General
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10-15-2013 09:40 AM
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
From the The DNP-NMR Blog:
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
Park, J.M., et al., Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging. Neuro-Oncology, 2013. 15(4): p. 433-41.
http://neuro-oncology.oxfordjournals.org/content/early/2013/01/16/neuonc.nos319.abstract
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News from NMR blogs
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04-15-2013 08:52 AM
NMR of hyperpolarised probes
From the The DNP-NMR Blog:
NMR of hyperpolarised probes
Witte, C. and L. Schroder, NMR of hyperpolarised probes. NMR Biomed, 2012: p. n/a-n/a.
http://www.ncbi.nlm.nih.gov/pubmed/23033215
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04-15-2013 08:52 AM
Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot
From the The DNP-NMR Blog:
Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot
Safiullin, K., C. Talbot, and P.J. Nacher, Achieving high spatial resolution and high SNR in low-field MRI of hyperpolarised gases with Slow Low Angle SHot. J Magn Reson, 2013. 227(0): p. 72-86.
http://dx.doi.org/10.1016/j.jmr.2012.11.025
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News from NMR blogs
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04-15-2013 08:52 AM
[NMR paper] Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan 17;
Authors: Xue S, Qiao J, Pu F, Cameron M, Yang JJ
Abstract
Magnetic...
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Journal club
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02-03-2013 10:19 AM
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
J Proteome Res. 2010 Dec 3;9(12):6729-39
Authors: Szeto SS, Reinke SN, Sykes BD, Lemire BD
Metabolomics is a powerful method of examining the intricate connections between mutations, metabolism, and disease. Metabolic...
Bolus tracking for improved metabolic imaging of hyperpolarised compounds
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