BioNMR
NMR aggregator & online community since 2003
BioNMR    
Learn or help to learn NMR - get free NMR books!
 

Go Back   BioNMR > NMR community > News from NMR blogs
Advanced Search
Home Forums Wiki NMR feeds Downloads Register Today's Posts



Jobs Groups Conferences Literature Pulse sequences Software forums Programs Sample preps Web resources BioNMR issues


Webservers
NMR processing:
MDD
NMR assignment:
Backbone:
Autoassign
MARS
UNIO Match
PINE
Side-chains:
UNIO ATNOS-Ascan
NOEs:
UNIO ATNOS-Candid
UNIO Candid
ASDP
Structure from NMR restraints:
Ab initio:
GeNMR
Cyana
XPLOR-NIH
ASDP
UNIO ATNOS-Candid
UNIO Candid
Fragment-based:
BMRB CS-Rosetta
Rosetta-NMR (Robetta)
Template-based:
GeNMR
I-TASSER
Refinement:
Amber
Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
BMRB CS-Rosetta
Homology-based:
CS23D
Simshift
Torsion angles from chemical shifts:
Preditor
TALOS
Promega- Proline
Secondary structure from chemical shifts:
CSI (via RCI server)
TALOS
MICS caps, β-turns
d2D
PECAN
Flexibility from chemical shifts:
RCI
Interactions from chemical shifts:
HADDOCK
Chemical shifts re-referencing:
Shiftcor
UNIO Shiftinspector
LACS
CheckShift
RefDB
NMR model quality:
NOEs, other restraints:
PROSESS
PSVS
RPF scores
iCing
Chemical shifts:
PROSESS
CheShift2
Vasco
iCing
RDCs:
DC
Anisofit
Pseudocontact shifts:
Anisofit
Protein geomtery:
Resolution-by-Proxy
PROSESS
What-If
iCing
PSVS
MolProbity
SAVES2 or SAVES4
Vadar
Prosa
ProQ
MetaMQAPII
PSQS
Eval123D
STAN
Ramachandran Plot
Rampage
ERRAT
Verify_3D
Harmony
Quality Control Check
NMR spectrum prediction:
FANDAS
MestReS
V-NMR
Flexibility from structure:
Backbone S2
Methyl S2
B-factor
Molecular dynamics:
Gromacs
Amber
Antechamber
Chemical shifts prediction:
From structure:
Shiftx2
Sparta+
Camshift
CH3shift- Methyl
ArShift- Aromatic
ShiftS
Proshift
PPM
CheShift-2- Cα
From sequence:
Shifty
Camcoil
Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
Validate NMR-STAR 3.1
NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
sedNMR


Reply
 
Thread Tools Search this Thread Rate Thread Display Modes
  #1  
Old 07-06-2018, 09:40 AM
nmrlearner's Avatar
Senior Member
 
Join Date: Jan 2005
Posts: 23,777
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 193,617
Downloads: 0
Uploads: 0
Default Biomolecular imaging of (13)C-butyrate with dissolution-DNP: Polarization enhancement and formulation for in vivo studies

From The DNP-NMR Blog:

Biomolecular imaging of (13)C-butyrate with dissolution-DNP: Polarization enhancement and formulation for in vivo studies

Flori, A., G. Giovannetti, M. F. Santarelli, G. D. Aquaro, D. De Marchi, S. Burchielli, F. Frijia, V. Positano, L. Landini, and L. Menichetti. “Biomolecular Imaging of (13)C-Butyrate with Dissolution-DNP: Polarization Enhancement and Formulation for in Vivo Studies.” Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 199 (June 15, 2018): 153–60.


https://doi.org/10.1016/j.saa.2018.03.014.


Magnetic Resonance Spectroscopy of hyperpolarized isotopically enriched molecules facilitates the non-invasive real-time investigation of in vivo tissue metabolism in the time-frame of a few minutes; this opens up a new avenue in the development of biomolecular probes. Dissolution Dynamic Nuclear Polarization is a hyperpolarization technique yielding a more than four orders of magnitude increase in the (13)C polarization for in vivo Magnetic Resonance Spectroscopy studies. As reported in several studies, the dissolution Dynamic Nuclear Polarization polarization performance relies on the chemico-physical properties of the sample. In this study, we describe and quantify the effects of the different sample components on the dissolution Dynamic Nuclear Polarization performance of [1-(13)C]butyrate. In particular, we focus on the polarization enhancement provided by the incremental addition of the glassy agent dimethyl sulfoxide and gadolinium chelate to the formulation. Finally, preliminary results obtained after injection in healthy rats are also reported, showing the feasibility of an in vivo Magnetic Resonance Spectroscopy study with hyperpolarized [1-(13)C]butyrate using a 3T clinical set-up.


Go to The DNP-NMR Blog for more info.
Reply With Quote


Did you find this post helpful? Yes | No

Reply
Similar Threads
Thread Thread Starter Forum Replies Last Post
Free Radical Imaging Using In Vivo Dynamic Nuclear Polarization-MRI #DNPNMR #ODNP
From The DNP-NMR Blog: Free Radical Imaging Using In Vivo Dynamic Nuclear Polarization-MRI #DNPNMR #ODNP p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Utsumi, H. and F. Hyodo, Free Radical Imaging Using In Vivo Dynamic Nuclear Polarization-MRI. Methods Enzymol, 2015. 564: p. 553-71. https://www.ncbi.nlm.nih.gov/pubmed/26477265
nmrlearner News from NMR blogs 0 08-18-2017 04:59 PM
NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization
From The DNP-NMR Blog: NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Pinto, L.F., et al., NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization. Chem Commun (Camb), 2017. 53(26): p. 3757-3760. https://www.ncbi.nlm.nih.gov/pubmed/28304028
nmrlearner News from NMR blogs 0 06-20-2017 01:56 AM
Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR
From The DNP-NMR Blog: Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions #DNPNMR p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Lee, Y., Dissolution dynamic nuclear polarization–enhanced magnetic resonance spectroscopy and imaging: Chemical and biochemical reactions in nonequilibrium conditions. Applied Spectroscopy Reviews, 2015. 51(3): p. 210-226. https://doi.org/10.1080/05704928.2015.1116078
nmrlearner News from NMR blogs 0 12-30-2016 04:53 PM
Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging #DNPNMR
From The DNP-NMR Blog: Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging #DNPNMR Korenchan, D.E., et al., Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb), 2016. 52(14): p. 3030-3. http://www.ncbi.nlm.nih.gov/pubmed/26792559
nmrlearner News from NMR blogs 0 06-02-2016 02:11 AM
Dissolution DNP for in vivo preclinical studies
From The DNP-NMR Blog: Dissolution DNP for in vivo preclinical studies Comment, A., Dissolution DNP for in vivo preclinical studies. J Magn Reson, 2016. 264: p. 39-48. http://www.ncbi.nlm.nih.gov/pubmed/26920829
nmrlearner News from NMR blogs 0 04-28-2016 02:04 AM
Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization
From The DNP-NMR Blog: Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization Bowen, S. and J.H. Ardenkjaer-Larsen, Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization. J Magn Reson, 2013. 236(0): p. 26-30. http://www.ncbi.nlm.nih.gov/pubmed/24036470
nmrlearner News from NMR blogs 0 12-02-2013 11:48 PM
Recovering lost magnetization: polarization enhancement in biomolecular NMR
Recovering lost magnetization: polarization enhancement in biomolecular NMR Abstract Experimental sensitivity remains a major drawback for the application of NMR spectroscopy to fragile and low concentrated biomolecular samples. Here we describe an efficient polarization enhancement mechanism in longitudinal-relaxation enhanced fast-pulsing triple-resonance experiments. By recovering undetectable 1H polarization originating from longitudinal relaxation during the pulse sequence, the steady-state 15N polarization becomes enhanced by up to a factor of ~5 with respect to thermal...
nmrlearner Journal club 0 12-31-2010 08:38 PM
Recovering lost magnetization: polarization enhancement in biomolecular NMR.
Recovering lost magnetization: polarization enhancement in biomolecular NMR. Recovering lost magnetization: polarization enhancement in biomolecular NMR. J Biomol NMR. 2010 Dec 30; Authors: Favier A, Brutscher B Experimental sensitivity remains a major drawback for the application of NMR spectroscopy to fragile and low concentrated biomolecular samples. Here we describe an efficient polarization enhancement mechanism in longitudinal-relaxation enhanced fast-pulsing triple-resonance experiments. By recovering undetectable (1)H polarization...
nmrlearner Journal club 0 12-31-2010 07:03 PM



Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off



BioNMR advertisements to pay for website hosting and domain registration. Nobody does it for us.



Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Copyright, BioNMR.com, 2003-2013
Search Engine Friendly URLs by vBSEO 3.6.0

All times are GMT. The time now is 01:38 PM.


Map