Félix-González, N., et al., Assessment of a Heuristic Model for Characterization of Magnetic Nanoparticles as Contrast Agent in MRI. Concepts in Magnetic Resonance Part A, 2015. 44A(5): p. 279-286.
In magnetic resonance imaging (MRI), the use of magnetic nanoparticles (MNPs) as contrast agent (CA) greatly enhances the possibility to identify several diseases hardly diagnosed by other means. The efficacy of a new CA is described by the longitudinal and transverse relaxivity. Nuclear Magnetic Relaxation Dispersion (NMRD) profiles represent the evolution of relaxivities with magnetic field. Many efforts have been taken to develop theoretical models to depict water proton relaxation in presence of magnetic compounds. The use of theoretical models in junction with NMRD profiles has become a powerful tool to characterize MNPs as CA. In this work, a heuristical theoretical model was implemented, verified and assessed with different magnetic materials. It has been demonstrated that the model works well when using iron cores but fails with other magnetic compounds. A weighting factor associated with Langevin function was introduced to the model. This extra calibration enables the model to be used with other magnetic compounds to characterize new CAs in MRI.
Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging
From The DNP-NMR Blog:
Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging
Kiryutin, A.S., et al., Long-lived spin states as a source of contrast in magnetic resonance spectroscopy and imaging. J Magn Reson, 2015. 261: p. 64-72.
http://www.ncbi.nlm.nih.gov/pubmed/26529204
nmrlearner
News from NMR blogs
0
03-25-2016 04:12 PM
Cucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent
From The DNP-NMR Blog:
Cucurbituril is an ultrasensitive (129)Xe NMR contrast agent
Wang, Y. and I.J. Dmochowski, Cucurbituril is an ultrasensitive (129)Xe NMR contrast agent. Chem Commun (Camb), 2015. 51(43): p. 8982-5.
http://www.ncbi.nlm.nih.gov/pubmed/25929681
nmrlearner
News from NMR blogs
0
06-11-2015 05:15 AM
[NMR paper] NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element.
NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png Related Articles NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element.
PLoS One. 2014;9(9):e108231
Authors: Chirayil S, Wu Q, Amezcua C, Luebke KJ
Abstract
We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21. This predicted stem-loop...
nmrlearner
Journal club
0
09-25-2014 11:57 PM
Progress in the characterization of bio-functionalized nanoparticles using NMR methods and their applications as MRI contrast agents
Progress in the characterization of bio-functionalized nanoparticles using NMR methods and their applications as MRI contrast agents
Publication date: Available online 1 February 2014
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Rita López-Cebral , Manuel Martín-Pastor , Begoña Seijo , Alejandro Sanchez</br>
Significant progress has been made over the last three decades in the field of NMR, a technique which has proven to have a variety of applications in many scientific disciplines, including nanotechnology. Herein we describe how...
nmrlearner
Journal club
0
02-03-2014 03:18 AM
[NMR paper] NMR characterization of theinteraction of GroEL with amyloid ? as a model ligand.
NMR characterization of theinteraction of GroEL with amyloid ? as a model ligand.
Related Articles NMR characterization of theinteraction of GroEL with amyloid ? as a model ligand.
FEBS Lett. 2013 Apr 18;
Authors: Yagi-Utsumi M, Kunihara T, Nakamura T, Uekusa Y, Makabe K, Kuwajima K, Kato K
Abstract
Here we report an NMR study on the substrate interaction modes of GroEL using amyloid?(A?) as a model ligand. We found that GroEL could suppress A?(1-40) amyloid formation by interacting with its two hydrophobic segments Leu17-Ala21 and...
nmrlearner
Journal club
0
04-23-2013 08:37 PM
[NMR paper] The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy.
The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy.
Magn Reson Med. 2012 Oct;68(4):1026-38
Authors: Benahmed MA,...
nmrlearner
Journal club
0
03-09-2013 11:05 AM
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.
NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.
Chem Commun (Camb). 2011 Jun 14;47(22):6407-9
Authors: Shoshan MS, Shalev DE, Adriaens W, Merkx M, Hackeng TM, Tshuva EY
Abstract
The first NMR structure of a Cu(I)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ~3.0 and ~6.8 Cu(I) binds through one Cys and the Met...
nmrlearner
Journal club
0
09-21-2011 03:31 PM
[NMR paper] Contrast agents for magnetic resonance angiographic applications: 1H and 17O NMR rela
Contrast agents for magnetic resonance angiographic applications: 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin.
Related Articles Contrast agents for magnetic resonance angiographic applications: 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin.
J Biol Inorg Chem. 1999 Dec;4(6):766-74
Authors: Aime S, Chiaussa M, Digilio G, Gianolio E, Terreno E
The...
Assessment of a Heuristic Model for Characterization of Magnetic Nanoparticles as Contrast Agent in MRI
Linear Mode
