The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ~6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.
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Facet dependent pairwise addition of hydrogen over Pd nanocrystal catalysts revealed via NMR using para-hydrogen-induced polarization
From The DNP-NMR Blog:
Facet dependent pairwise addition of hydrogen over Pd nanocrystal catalysts revealed via NMR using para-hydrogen-induced polarization
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Wang, W., et al., Facet dependent pairwise addition of hydrogen over Pd nanocrystal catalysts revealed via NMR using para-hydrogen-induced polarization. Phys. Chem. Chem. Phys., 2017. 19(14): p. 9349-9353.
https://www.ncbi.nlm.nih.gov/pubmed/28138682
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06-22-2017 07:44 AM
Dipolar induced Para-Hydrogen-Induced Polarization
From The DNP-NMR Blog:
Dipolar induced Para-Hydrogen-Induced Polarization
Buntkowsky, G., et al., Dipolar induced Para-Hydrogen-Induced Polarization. Solid State Nucl Magn Reson, 2014. 63-64(0): p. 20-9.
http://www.ncbi.nlm.nih.gov/pubmed/25218522
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12-10-2014 06:29 PM
Dipolar Induced Para-Hydrogen-Induced Polarization
From The DNP-NMR Blog:
Dipolar Induced Para-Hydrogen-Induced Polarization
Buntkowsky, G., et al., Dipolar Induced Para-Hydrogen-Induced Polarization. Solid State Nuclear Magnetic Resonance, 2014(0).
http://www.sciencedirect.com/science/article/pii/S0926204014000502
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09-11-2014 12:06 AM
[NMR paper] Para-hydrogen perspectives in hyperpolarized NMR.
Para-hydrogen perspectives in hyperpolarized NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Para-hydrogen perspectives in hyperpolarized NMR.
J Magn Reson. 2013 Oct;235:130-42
Authors: Glöggler S, Colell J, Appelt S
Abstract
The first instance of para-hydrogen induced polarization (PHIP) in an NMR experiment was serendipitously observed in the 1980s while investigating a hydrogenation reaction (Seldler et al., 1983; Bowers and...
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04-23-2014 06:31 PM
Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments
From The DNP-NMR Blog:
Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments
Pravdivtsev, A.N., et al., Level Anti-Crossings are a Key Factor for Understanding para-Hydrogen-Induced Hyperpolarization in SABRE Experiments. ChemPhysChem, 2013. 14(14): p. 3327-3331.
http://www.ncbi.nlm.nih.gov/pubmed/23959909
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04-16-2014 11:09 PM
Evidence for Coherent Transfer of para-Hydrogen-Induced Polarization at Low Magnetic Fields
From The DNP-NMR Blog:
Evidence for Coherent Transfer of para-Hydrogen-Induced Polarization at Low Magnetic Fields
Kiryutin, A.S., et al., Evidence for Coherent Transfer of para-Hydrogen-Induced Polarization at Low Magnetic Fields. The Journal of Physical Chemistry Letters, 2013. 4(15): p. 2514-2519.
http://dx.doi.org/10.1021/jz401210m
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11-21-2013 01:14 AM
High Resolution Para-Hydrogen Induced Polarization in Inhomogeneous Magnetic Fields
From the The DNP-NMR Blog:
High Resolution Para-Hydrogen Induced Polarization in Inhomogeneous Magnetic Fields
Buljubasich, L., et al., High Resolution Para-Hydrogen Induced Polarization in Inhomogeneous Magnetic Fields. J. Magn. Reson., 2013(0).
http://dx.doi.org/10.1016/j.jmr.2013.02.008