Jeong, Hye Jin, Sein Min, and Keunhong Jeong. “Analysis of 1-Aminoisoquinoline Using the Signal Amplification by Reversible Exchange Hyperpolarization Technique.” The Analyst, 2020, 10.1039.D0AN00967A.
Signal amplification by reversible exchange (SABRE), a parahydrogen-based hyperpolarization technique, is valuable in detecting low concentrations of chemical compounds, which facilitates the understanding of their functions at molecular level as well as their applicability in nuclear magnetic resonance (NMR) and magentic resource maging (MRI). SABRE of 1- aminoisoquinoline (1-AIQ) is significant because isoquinoline derivatives are the fundamental structures in compounds with notable biological activity and are basic organic building blocks. Through this study, we explain how SABRE is applied to hyperpolarize 1-AIQ for diverse solvent systems such as deuterium and non-deuterium solvents. We observed the amplification of individual protons of 1-AIQ at various magnetic fields. Further, we describe the polarization transfer mechanism of 1-AIQ compared to pyridine using density functional theory (DFT) calculations. These hyperpolarization techniques, including the polarization transfer mechanism investigation on 1-AIQ, will provide a firm basis for the future application of the hyperpolarization study on various bio-friendly materials.
Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange
From The DNP-NMR Blog:
Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange
Kim, Sarah, Sein Min, Heelim Chae, Hye Jin Jeong, Sung Keon Namgoong, Sangwon Oh, and Keunhong Jeong. “Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange.” Molecules 25, no. 15 (July 23, 2020): 3347.
https://doi.org/10.3390/molecules25153347.
Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from...
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10-19-2020 05:07 PM
Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging
From The DNP-NMR Blog:
Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging
Robertson, Thomas B.R., and Ryan E. Mewis. “Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging.” In Annual Reports on NMR Spectroscopy, 93:145–212. Elsevier, 2018.
https://doi.org/10.1016/bs.arnmr.2017.08.001.
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11-25-2018 06:02 AM
Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange
From The DNP-NMR Blog:
Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange
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Rayner, P.J., et al., Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proc Natl Acad Sci U S A, 2017. 114(16): p. E3188-E3194.
https://www.ncbi.nlm.nih.gov/pubmed/28377523
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04-28-2017 02:27 PM
Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei
From The DNP-NMR Blog:
Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei
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Olaru, A.M., et al., Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei. Chem Commun (Camb), 2016. 52(100): p. 14482-14485.
https://www.ncbi.nlm.nih.gov/pubmed/27904890
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02-17-2017 09:56 PM
Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields
From The DNP-NMR Blog:
Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields
Pravdivtsev, A.N., et al., Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields. Appl. Magn. Reson., 2016. 47(7): p. 711-725.
http://dx.doi.org/10.1007/s00723-016-0771-y
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07-25-2016 04:26 PM
Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)
From The DNP-NMR Blog:
Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)
Moreno, K.X., et al., Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE). J Magn Reson, 2015. 257: p. 15-23.
http://www.ncbi.nlm.nih.gov/pubmed/26037136
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09-11-2015 07:42 PM
Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange
From The DNP-NMR Blog:
Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange
Truong, M.L., et al., Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry B, 2014. 118(48): p. 13882-13889.
http://dx.doi.org/10.1021/jp510825b
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04-15-2015 04:40 PM
The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
From The DNP-NMR Blog:
The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
Barskiy, D.A., et al., The feasibility of formation and kinetics of NMR signal amplification by reversible exchange (SABRE) at high magnetic field (9.4 T). J Am Chem Soc, 2014. 136(9): p. 3322-5.
http://www.ncbi.nlm.nih.gov/pubmed/24528143
Analysis of 1-aminoisoquinoline using the signal amplification by reversible exchange hyperpolarization technique #SABRE
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