X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases.
Methods. 2013 Jul 27;
Authors: Elena Gulerez I, Gehring K
Abstract
Protein tyrosine phosphatases (PTPs) are well recognized as key targets in a wide spectrum of diseases, such as diabetes, obesity and cancer. Their roles in these maladies have been successfully characterized by various methods. However, it is only by utilizing the entire gamut of tools and techniques available that we can build a sufficient knowledge of their mode of action to bridge the gap between bench work and bedside treatments. Here, we highlight X-ray crystallography and NMR for the study of PTPs and describe methodological aspects of their use. These techniques are highly developed, versatile methods that together afford insight into protein dynamics, function and three-dimensional structure. They provide the detail necessary for the structure-based design and identification of lead compounds with potential as PTP-specific drugs for therapeutic use.
PMID: 23899694 [PubMed - as supplied by publisher]
X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases
X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases
Publication date: Available online 27 July 2013
Source:Methods</br>
Author(s): Irina Elena Gulerez , Kalle Gehring</br>
Protein tyrosine phosphatases (PTPs) are well recognized as key targets in a wide spectrum of diseases, such as diabetes, obesity and cancer. Their roles in these maladies have been successfully characterized by various methods. However, it is only by utilizing the entire gamut of tools and techniques available that we can build a sufficient knowledge of their...
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Postdoctoral position to study Protein-Protein Interactions and their role in Mechanisms of Signal Transduction using protein solution NMR/x-ray crystallography
Spincore.com are advertising a postdoc NMR position. It sounds pretty interesting.
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Postdoctoral position to study Protein-Protein Interactions and their role in Mechanisms of Signal Transduction using protein solution NMR /x-ray crystallography
Case Medical School, Cleveland, Ohio, USA
How are signaling events transmitted from one protein to another? To answer this question we are looking to add a postdoctoral co-workers to our interdisciplinary team. Our interest is to understand protein-protein interactions, protein structure and dynamics in the context of cell signaling...
X-ray crystallography and NMR as tools for the study of protein tyrosine phosphatases.
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