[NMR paper] Urinary (1)H-NMR metabolomic fingerprinting reveals biomarkers of pulse consumption related to energy metabolism modulation in a subcohort from the PREDIMED study.
Urinary (1)H-NMR metabolomic fingerprinting reveals biomarkers of pulse consumption related to energy metabolism modulation in a subcohort from the PREDIMED study.
Related ArticlesUrinary (1)H-NMR metabolomic fingerprinting reveals biomarkers of pulse consumption related to energy metabolism modulation in a subcohort from the PREDIMED study.
J Proteome Res. 2017 Jan 09;:
Authors: Madrid-Gambin F, Llorach R, Vázquez-Fresno R, Urpi-Sarda M, Almanza-Aguilera E, Garcia-Aloy M, Estruch R, Corella D, Andres-Lacueva C
Abstract
Little is known about the metabolome fingerprint of pulse consumption. The study of robust and accurate biomarkers for pulse dietary assessment has great value for nutritional epidemiology regarding health benefits and their mechanisms. To characterize the fingerprinting of dietary pulses (chickpeas, lentils and beans), spot urine samples from a subcohort from the PREDIMED study were stratified, using a validated food frequency questionnaire. Non-pulse consumers (= 25 g/day of pulse intake) were analysed using a 1H-NMR metabolomics approach combined with multi- and univariate data analysis. Pulse consumption showed differences through 16 metabolites coming from (i) choline metabolism, (ii) protein-related compounds, and (iii) energy metabolism (including lower urinary glucose). Stepwise logistic regression analysis was applied to design a combined model of pulse exposure, which resulted in glutamine, dimethylamine and 3-methylhistidine. This model was evaluated by receiver operating characteristic curve (AUC > 90% in both training and validation sets). The application of NMR-based metabolomics to pulse exposure highlighted new candidates for biomarkers of pulse consumption, the role of choline metabolism and the impact on energy metabolism, generating new hypotheses on energy modulation. Further intervention studies will confirm these findings.
PMID: 28067528 [PubMed - as supplied by publisher]
[NMR paper] Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
Food Funct. 2015 Apr;6(4):1090-7
Authors: Moazzami AA, Frank S, Gombert A, Sus N, Bayram B, Rimbach G, Frank J
Abstract
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Trimethylphosphine-AssistedSurface Fingerprinting of Metal Oxide Nanoparticle by 31P Solid-State NMR: A Zinc Oxide Case Study
Trimethylphosphine-AssistedSurface Fingerprinting of Metal Oxide Nanoparticle by 31P Solid-State NMR: A Zinc Oxide Case Study
Yung-Kang Peng, Lin Ye, Jin Qu, Li Zhang, Yingyi Fu, Ivo F. Teixeira, Ian James McPherson, Heyong He and Shik Chi Edman Tsang
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b12080/20160210/images/medium/ja-2015-120807_0008.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b12080
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA...
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Metabolomic Study Uncovers Obesity-related Urine Signature - GenomeWeb
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Metabolomic Study Uncovers Obesity-related Urine Signature
GenomeWeb
As part of the International Study of Macro- and Micronutrients and Blood Pressure, or INTERMAP, the team used a combination of nuclear magnetic resonance spectroscopy and ion exchange chromatography to track metabolite patterns in urine samples ...
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Metabolomic Study Uncovers Obesity-related Urine Signature - GenomeWeb
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[NMR paper] r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
Related Articles r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
J Magn Reson. 2014 Apr 24;244C:68-73
Authors: Equbal A, Paul S, Mithu VS, Vinther JM, Nielsen NC, Madhu PK
Abstract
We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves...
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[NMR paper] Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
J Physiol Biochem. 2013 Jan 19;
Authors: Etxeberria U, de la Garza AL, Martínez JA, Milagro FI
Abstract
Metabolomics is a high-throughput tool...
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1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal
1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal
15 May–1 June 2013
Publication year: 2013
Source:Food Chemistry, Volume 138, Issues 2–3</br>
</br>
The use of NMR metabolomics in clinical trials is growing; however, reports of postprandial experiments in humans are scarce. The present study investigated whether consumption of lingonberries as a supplement to an oil-rich meal modifies the postprandial fingerprints of human urine. Urine samples were analysed by 1H NMR, and untargeted...
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NMR Metabolomic Profiling Reveals New Roles of SUMOylation in DNA Damage Response.
NMR Metabolomic Profiling Reveals New Roles of SUMOylation in DNA Damage Response.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-acspubs.jpg Related Articles NMR Metabolomic Profiling Reveals New Roles of SUMOylation in DNA Damage Response.
J Proteome Res. 2010 Aug 9;
Authors: Cano KE, Li YJ, Chen Y
Post-translational modifications by the Small Ubiquitin-like Modifier (SUMO) family of proteins have been established as critical events in the cellular response to a wide range of DNA damaging reagents and radiation;...
Urinary (1)H-NMR metabolomic fingerprinting reveals biomarkers of pulse consumption related to energy metabolism modulation in a subcohort from the PREDIMED study.
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