G protein-coupled receptors can adopt many different conformational states, each of them exhibiting different restraints towards downstream signaling pathways. One promising strategy to identify and quantify this conformational landscape is to introduce a cysteine at a receptor site sensitive to different states and label this cysteine with a probe for detection. Here, the application of NMR of hyperpolarized ^(129)Xe for the detection of the conformational states of human neuropeptide Y2...
[NMR paper] Probing the Conformational States of Neurotensin Receptor 1 Variants*by NMR Site-Directed Methyl Labeling.
Probing the Conformational States of Neurotensin Receptor 1 Variants*by NMR Site-Directed Methyl Labeling.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-7388-69-wiley-full-text.png Related Articles Probing the Conformational States of Neurotensin Receptor 1 Variants*by NMR Site-Directed Methyl Labeling.
Chembiochem. 2020 Sep 02;:
Authors: Goba I, Goricanec D, Schum D, Hillenbrand M, Plückthun A, Hagn F
Abstract
G-protein coupled receptors are key players mediating signal...
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A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
From The DNP-NMR Blog:
A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
Virgincar, Rohan S., Jerry Dahlke, Scott H. Robertson, Nathann Morand, Yi Qi, Simone Degan, Bastiaan Driehuys, and John C. Nouls. “A Portable Ventilator with Integrated Physiologic Monitoring for Hyperpolarized 129Xe MRI in Rodents.” Journal of Magnetic Resonance 295 (October 2018): 63–71.
https://doi.org/10.1016/j.jmr.2018.07.017.
Hyperpolarized (HP) 129Xe MRI is emerging as a powerful, non-invasive method to image lung function and is beginning to find...
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03-24-2019 10:41 PM
A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
From The DNP-NMR Blog:
A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
Virgincar, Rohan S., Jerry Dahlke, Scott H. Robertson, Nathann Morand, Yi Qi, Simone Degan, Bastiaan Driehuys, and John C. Nouls. “A Portable Ventilator with Integrated Physiologic Monitoring for Hyperpolarized 129Xe MRI in Rodents.” Journal of Magnetic Resonance 295 (October 2018): 63–71.
https://doi.org/10.1016/j.jmr.2018.07.017.
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11-25-2018 06:02 AM
Quantitative biosensor detection by chemically exchanging hyperpolarized 129Xe
From The DNP-NMR Blog:
Quantitative biosensor detection by chemically exchanging hyperpolarized 129Xe
Korchak, S., et al., Quantitative biosensor detection by chemically exchanging hyperpolarized 129Xe. PCCP, 2018. 20(3): p. 1800-1808.
http://dx.doi.org/10.1039/C7CP07051A
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03-17-2018 12:12 PM
Post-doc in hyperpolarized 129Xe MRI - CEA Saclay, France
From The DNP-NMR Blog:
Post-doc in hyperpolarized 129Xe MRI - CEA Saclay, France
From the Ampere Magnetic Resonance List:
A project untitled: « Polarized Xenon-MRI for diagnosis and follow up of Chest Tumors » is granted by the French programme « Projets de recherche dans le domaine de la physique, des mathématiques ou des sciences de l'ingénieur appliqués au cancer ».
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05-16-2014 08:06 PM
[NMR paper] Frontispiece: probing transient conformational States of proteins by solid-state r1? relaxation-dispersion NMR spectroscopy.
Frontispiece: probing transient conformational States of proteins by solid-state r1? relaxation-dispersion NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Frontispiece: probing transient conformational States of proteins by solid-state r1? relaxation-dispersion NMR spectroscopy.
Angew Chem Int Ed Engl. 2014 Apr 22;53(17)
Authors: Ma P, Haller JD, Zajakala J, Macek P, Sivertsen AC, Willbold D, Boisbouvier J,...
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[NMR paper] Probing Transient Conformational States of Proteins by Solid-State R1? Relaxation-Dispersion NMR Spectroscopy.
Probing Transient Conformational States of Proteins by Solid-State R1? Relaxation-Dispersion NMR Spectroscopy.
Related Articles Probing Transient Conformational States of Proteins by Solid-State R1? Relaxation-Dispersion NMR Spectroscopy.
Angew Chem Int Ed Engl. 2014 Mar 18;
Authors: Ma P, Haller JD, Zajakala J, Macek P, Sivertsen AC, Willbold D, Boisbouvier J, Schanda P
Abstract
The function of proteins depends on their ability to sample a variety of states differing in structure and free energy. Deciphering how the various thermally...
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03-20-2014 12:44 PM
Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate
From the The DNP-NMR Blog:
Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate
Barb, A.W., et al., Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate. J. Magn. Reson., 2013. 228(0): p. 59-65.
http://dx.doi.org/10.1016/j.jmr.2012.12.013
Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR
Linear Mode
