NMR paper Targeting the Small GTPase Superfamily through Their Regulatory Proteins

		BioNMR > Educational resources > Journal club
[NMR paper] Targeting the Small GTPase Superfamily through Their Regulatory Proteins

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

04-09-2020, 05:35 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Targeting the Small GTPase Superfamily through Their Regulatory Proteins

Targeting the Small GTPase Superfamily through Their Regulatory Proteins

Angewandte Chemie International Edition, Volume 59, Issue 16, Page 6342-6366, April 16, 2020.

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer - Science Advances Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer - Science Advances Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer Science Advances Read here	nmrlearner	Online News	0	02-29-2020 09:52 PM
[NMR paper] NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38. NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38. NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38. FEBS Lett. 2017 Nov 30;: Authors: De Cicco M, Kiss L, Dames SA Abstract Ras homologue enriched in brain (Rheb) is a small GTPase that regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) and, thereby, cell growth and metabolism. Cycling between the inactive GDP- and the active...	nmrlearner	Journal club	0	12-02-2017 02:54 PM
Molecular Simulations Reveal an Unresolved Conformationof the Type IA Protein Kinase A Regulatory Subunit and Suggest ItsRole in the cAMP Regulatory Mechanism Molecular Simulations Reveal an Unresolved Conformationof the Type IA Protein Kinase A Regulatory Subunit and Suggest ItsRole in the cAMP Regulatory Mechanism http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00461/20170717/images/medium/bi-2017-00461q_0003.gif Biochemistry DOI: 10.1021/acs.biochem.7b00461 http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/pu40kY-RYM0 More...	nmrlearner	Journal club	0	07-18-2017 07:52 AM
[NMR paper] Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy. Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy. Related Articles Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy. Biochem Biophys Res Commun. 2013 Dec 13; Authors: Shin JS, Ha JH, Chi SW Abstract Inhibition of the interaction between the p53 tumor suppressor and its negative regulator MDM2 is of great importance to cancer therapy. The anti-apoptotic Bcl-2 family proteins are also attractive anti-cancer molecular...	nmrlearner	Journal club	0	12-18-2013 04:00 PM
Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy Targeting of p53 Peptide Analogues to Anti-Apoptotic Bcl-2 Family Proteins as Revealed by NMR Spectroscopy Publication date: Available online 14 December 2013 Source:Biochemical and Biophysical Research Communications</br> Author(s): Jae-Sun Shin , Ji-Hyang Ha , Seung-Wook Chi</br> Inhibition of the interaction between the p53 tumor suppressor and its negative regulator MDM2 is of great importance to cancer therapy. The anti-apoptotic Bcl-2 family proteins are also attractive anti-cancer molecular targets, as they are key regulators of apoptotic cell death....	nmrlearner	Journal club	0	12-14-2013 04:48 PM
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors - Nature.com Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors - Nature.com <img alt="" height="1" width="1" /> Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors Nature.com In hepatocytes, GK regulates glucose uptake and glycogen synthesis, suppresses glucose production3, 5, and is subject to the endogenous inhibitor GK regulatory protein (GKRP)6, 7, 8. During fasting, GKRP binds, inactivates and ..... 1H-, 13C- and 19F ... Read here	nmrlearner	Online News	0	11-16-2013 03:09 AM
Integrated Computational Approach to the Analysis of NMR Relaxation in Proteins: Application to ps-ns Main Chain (15)N-(1)H and Global Dynamics of the Rho GTPase Binding Domain of Plexin-B1. Integrated Computational Approach to the Analysis of NMR Relaxation in Proteins: Application to ps-ns Main Chain (15)N-(1)H and Global Dynamics of the Rho GTPase Binding Domain of Plexin-B1. Integrated Computational Approach to the Analysis of NMR Relaxation in Proteins: Application to ps-ns Main Chain (15)N-(1)H and Global Dynamics of the Rho GTPase Binding Domain of Plexin-B1. J Phys Chem B. 2010 Dec 10; Authors: Zerbetto M, Buck M, Meirovitch E, Polimeno A	nmrlearner	Journal club	0	12-15-2010 12:03 PM
[MWClarkson blog] Dynamics conservation in the Ras superfamily Dynamics conservation in the Ras superfamily http://www.researchblogging.org/public/citation_icons/rb2_large_gray.pngThe proposition that general fold architecture is preserved within a family of evolutionarily-related proteins is not controversial. The amino acid sequence of a protein determines its structure, and countless studies have substantiated the idea that proteins with similar sequences will adopt similar folded conformations. Because structure and dynamics are intrinsically linked, one could reasonably assume that many features of a protein's dynamics get conserved along with...	nmrlearner	News from NMR blogs	0	08-22-2010 01:58 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off