[NMR paper] Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
[ASAP] Partial Consensus Design and Enhancement of Protein Function by Secondary-Structure-Guided Consensus Mutations
Partial Consensus Design and Enhancement of Protein Function by Secondary-Structure-Guided Consensus Mutations
https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.1c00309/20210713/images/medium/bi1c00309_0007.gif
Biochemistry
DOI: 10.1021/acs.biochem.1c00309
http://feeds.feedburner.com/~r/acs/bichaw/~4/J5d4_89szC4
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[NMR paper] 19F NMR as a versatile tool to study (membrane) protein structure and dynamics.
19F NMR as a versatile tool to study (membrane) protein structure and dynamics.
Related Articles 19F NMR as a versatile tool to study (membrane) protein structure and dynamics.
Biol Chem. 2018 Dec 01;:
Authors: Rose-Sperling D, Tran MA, Lauth LM, Goretzki B, Hellmich UA
Abstract
To elucidate the structures and dynamics of membrane proteins, highly advanced biophysical methods have been developed that often require significant resources, both for sample preparation and experimental analyses. For very complex systems, such as...
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[NMR paper] Structure-based design of scaffolds targeting PDE10A by INPHARMA-NMR.
Structure-based design of scaffolds targeting PDE10A by INPHARMA-NMR.
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J Chem Inf Model. 2017 May 31;:
Authors: Codutti L, Grimaldi M, Carlomagno T
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Phosphodiesterases (PDE) hydrolyze both cyclic AMP and GMP (cAMP/cGMP) and are responsible for the regulation of their levels in a multitude of cellular functions. PDE10A is...
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[NMR paper] High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.
ChemMedChem. 2015 Nov 23;
Authors: Bottini A, Wu B, Barile E, De SK, Leone M, Pellecchia M
Abstract
Recently we described a novel approach, named high-throughput screening (HTS) by NMR that allows the identification, from large combinatorial peptide libraries, of potent and selective...
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11-26-2015 12:13 AM
[NMR paper] Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.
Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients.
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Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17504-9
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[NMR paper] Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.
Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.
Conformational stabilization of the membrane embedded targeting domain of the lysosomal peptide transporter TAPL for solution NMR.
J Biomol NMR. 2013 Sep 7;
Authors: Tumulka F, Roos C, Löhr F, Bock C, Bernhard F, Dötsch V, Abele R
Abstract
The ATP binding cassette transporter TAPL translocates cytosolic peptides into the lumen of lysosomes driven by the hydrolysis of ATP. Functionally, this transporter can be...
Structure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
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