Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides are targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying these biological phenomena, atomic views are essential to delineate dynamic biomolecular interactions. Nuclear magnetic resonance (NMR) spectroscopy provides powerful tools for studying structures,...
[NMR paper] Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
Quantitative NMR for the structural analysis of novel bivalent glycoconjugates as vaccine candidates
Novel unimolecular bivalent glycoconjugates were assembled combining several functionalized capsular polysaccharides of Streptococcus pneumoniae and Neisseria meningitidis to a carrier protein by using an effective strategy based on the Ugi 4-component reaction. The development of multivalent glycoconjugates opens new opportunities in the field of vaccine design, but their high structural complexity involves new analytical challenges. Nuclear Magnetic Resonance has found wide applications...
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UncoveringNonconventional and Conventional HydrogenBonds in Oligosaccharides through NMR Experiments and Molecular Modeling:Application to Sialyl Lewis-X
UncoveringNonconventional and Conventional HydrogenBonds in Oligosaccharides through NMR Experiments and Molecular Modeling:Application to Sialyl Lewis-X
Marcos D. Battistel, Hugo F. Azurmendi, Martin Frank and Daro?n I. Freedberg
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b03824/20151015/images/medium/ja-2015-038244_0007.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b03824
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/ua2mIGR2q0k
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[NMR paper] Paramagnetic NMR probes for characterization of the dynamic conformations and interactions of oligosaccharides.
Paramagnetic NMR probes for characterization of the dynamic conformations and interactions of oligosaccharides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Paramagnetic NMR probes for characterization of the dynamic conformations and interactions of oligosaccharides.
Glycoconj J. 2015 Jun 7;
Authors: Kato K, Yamaguchi T
Abstract
Paramagnetism-assisted nuclear magnetic resonance (NMR) techniques have recently been applied to a wide variety...
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[NMR paper] Conformational studies of neurohypophyseal hormones analogues with glycoconjugates by NMR spectroscopy.
Conformational studies of neurohypophyseal hormones analogues with glycoconjugates by NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Conformational studies of neurohypophyseal hormones analogues with glycoconjugates by NMR spectroscopy.
J Pept Sci. 2014 Jun;20(6):406-14
Authors: Lubecka EA, Sikorska E, Marcinkowska A, Ciarkowski J
Abstract
Two glycosylated peptides have been studied using NMR...
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12-30-2014 03:28 PM
[NMR paper] Structural analysis of oligosaccharides and glycoconjugates using NMR.
Structural analysis of oligosaccharides and glycoconjugates using NMR.
Related Articles Structural analysis of oligosaccharides and glycoconjugates using NMR.
Adv Neurobiol. 2014;9:165-83
Authors: Yamaguchi Y, Yamaguchi T, Kato K
Abstract
Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides are targets for various amyloidogenic proteins associated with neurodegenerative disorders. To better understand the molecular mechanisms underlying...
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08-26-2014 01:25 PM
The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.
The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.
The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.
J Biol Inorg Chem. 2011 Apr 3;
Authors: Teixeira JM, Dias DM, Cañada FJ, Martins JA, André JP, Jiménez-Barbero J, Geraldes CF
The study of ligand-receptor interactions using high-resolution NMR techniques, namely the saturation transfer difference (STD),...
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04-05-2011 10:22 PM
Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy.
Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy.
Dynamics and interactions of glycoconjugates probed by stable-isotope-assisted NMR spectroscopy.
Methods Enzymol. 2010;478:305-22
Authors: Yamaguchi Y, Kato K
Unique advantages offered by nuclear magnetic resonance (NMR) spectroscopy provide high-resolution information not only on structures but also on dynamics and interactions of glycoconjugates in solution. These benefits are further enhanced by applying stable-isotope-labeling techniques, which we...
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12-31-2010 07:03 PM
[NMR paper] Structure and dynamics of oligosaccharides: NMR and modeling studies.
Structure and dynamics of oligosaccharides: NMR and modeling studies.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Structure and dynamics of oligosaccharides: NMR and modeling studies.
Curr Opin Struct Biol. 1996 Oct;6(5):710-20
Authors: Peters T, Pinto BM
Recent advances in the conformational analysis of oligosaccharides have focused on protein-bound oligosaccharides, glycopeptides, and glycoproteins, as well as on the conformational dynamics about glycosidic...
Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR
Linear Mode
