Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements.
Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements.
Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements.
J Struct Biol. 2011 Apr 9;
Authors: Kodama Y, Reese ML, Shimba N, Ono K, Kanamori E, Dötsch V, Noguchi S, Fukunishi Y, Suzuki EI, Shimada I, Takahashi H
Protein-protein interactions are necessary for various cellular...
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04-20-2011 07:15 PM
[NMR paper] Insulin allosteric behavior: detection, identification, and quantification of alloste
Insulin allosteric behavior: detection, identification, and quantification of allosteric states via 19F NMR.
Related Articles Insulin allosteric behavior: detection, identification, and quantification of allosteric states via 19F NMR.
Biochemistry. 2005 May 31;44(21):7656-68
Authors: Bonaccio M, Ghaderi N, Borchardt D, Dunn MF
The insulin hexamer is an allosteric protein widely used in formulations for the treatment of diabetes. The hexamer exhibits positive and negative cooperativity and apparent half-site binding activity, reflecting the...
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11-25-2010 08:21 PM
[NMR paper] Identification and optimization of protein domains for NMR studies.
Identification and optimization of protein domains for NMR studies.
Related Articles Identification and optimization of protein domains for NMR studies.
Methods Enzymol. 2005;394:3-16
Authors: Card PB, Gardner KH
The success of genomic sequencing projects in recent years has presented protein scientists with a formidable challenge in characterizing the vast number of gene products that have subsequently been identified. NMR has proven to be a valuable tool in the elucidation of various properties for many of these proteins, allowing versatile...
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11-24-2010 11:14 PM
[NMR paper] NMR-based methods and strategies for drug discovery.
NMR-based methods and strategies for drug discovery.
Related Articles NMR-based methods and strategies for drug discovery.
Chem Soc Rev. 2003 Nov;32(6):365-72
Authors: Salvatella X, Giralt E
Nuclear Magnetic Resonance (NMR) spectroscopy has long been a favourite tool of chemists interested in host-guest systems because it permits access to a wealth of information about the molecular recognition reaction. NMR has evolved dramatically in the last 15 years and, in parallel with the development of NMR methods for the determination of protein...
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11-24-2010 09:16 PM
[NMR paper] In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5
In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
Related Articles In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction.
J Med Chem. 2002 Dec 19;45(26):5655-60
Authors: Kamionka M, Rehm T, Beisel HG, Lang K, Engh RA, Holak TA
Recently we have determined the crystal structure of the insulin-like growth factor-I (IGF-I) in complex with the N-terminal domain of the IGF-binding protein-5 (IGFBP-5). Here we report results of computer screening for...
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11-24-2010 08:58 PM
[NMR paper] NMR-based modification of matrix metalloproteinase inhibitors with improved bioavaila
NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.
Related Articles NMR-based modification of matrix metalloproteinase inhibitors with improved bioavailability.
J Med Chem. 2002 Dec 19;45(26):5628-39
Authors: Hajduk PJ, Shuker SB, Nettesheim DG, Craig R, Augeri DJ, Betebenner D, Albert DH, Guo Y, Meadows RP, Xu L, Michaelides M, Davidsen SK, Fesik SW
The NMR-based discovery of biaryl hydroxamate inhibitors of the matrix metalloproteinase stromelysin (MMP-3) has been previously described (Hajduk et al....
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11-24-2010 08:58 PM
[NMR paper] Probability-based protein secondary structure identification using combined NMR chemi
Probability-based protein secondary structure identification using combined NMR chemical-shift data.
Related Articles Probability-based protein secondary structure identification using combined NMR chemical-shift data.
Protein Sci. 2002 Apr;11(4):852-61
Authors: Wang Y, Jardetzky O
For a long time, NMR chemical shifts have been used to identify protein secondary structures. Currently, this is accomplished through comparing the observed (1)H(alpha), (13)C(alpha), (13)C(beta), or (13)C' chemical shifts with the random coil values. Here, we...
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11-24-2010 08:49 PM
[NMR paper] NMR-based discovery of lead inhibitors that block DNA binding of the human papillomav
NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-acspubs.jpg Related Articles NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
J Med Chem. 1997 Sep 26;40(20):3144-50
Authors: Hajduk PJ, Dinges J, Miknis GF, Merlock M, Middleton T, Kempf DJ, Egan DA, Walter KA, Robins TS, Shuker SB, Holzman TF, Fesik SW
The E2 protein is required for the replication of human...
Strategies for the NMR-based identification and optimization of allosteric protein kinase inhibitors.
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